Spatial Relationship Between Merkel Cells and Langerhans Cells in Human Hair Follicles

The study investigated the spatial relationship between Merkel cells and Langerhans cells in human hair follicles, using immunohistochemical staining techniques. It was found that a small proportion of Merkel cells were closely contacted with Langerhans cells below the sebaceous gland level, likely in the bulge area. This close anatomical relationship, observed for the first time, suggests a functional interaction between these cells, potentially involving communication through dendrites that may store neuropeptides or cytokines.