Spatial Relationship Between Merkel Cells and Langerhans Cells in Human Hair Follicles

The study investigated the spatial relationship between Merkel cells and Langerhans cells in human hair follicles. Using immunohistochemical staining and double staining techniques, it was found that a small proportion of Merkel cells were in close contact with Langerhans cells below the sebaceous gland level, likely in the bulge area. This area is significant as it may contain follicular stem cells. The findings suggested a functional interaction between these two cell types, potentially involving communication through dendrites that store neuropeptides or cytokines. This was the first demonstration of a close anatomical relationship between Merkel cells and Langerhans cells in the bulge area of human hair follicles.