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GlossaryNeuropeptides

small protein-like molecules that neurons use to communicate

Neuropeptides are small protein-like molecules used by neurons to communicate with each other. They influence a variety of brain functions, including pain perception, reward, food intake, metabolism, reproduction, social behaviors, and learning. In the context of hair and alopecia, neuropeptides can affect hair growth by modulating the activity of hair follicle cells and influencing the local immune response.

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Neuronal Plasticity of the Brain-Skin Connection: Stress-Triggered Up-Regulation of Neuropeptides in Dorsal Root Ganglia and Skin via Nerve Growth Factor-Dependent Pathways

research Neuronal Plasticity of the Brain-Skin Connection: Stress-Triggered Up-Regulation of Neuropeptides in Dorsal Root Ganglia and Skin via Nerve Growth Factor-Dependent Pathways

66 citations, July 2007 in “Journal of Molecular Medicine”

Stress increases certain chemicals in the skin and nerves, which might worsen skin conditions.

research Trichodynia Revisited

4 citations, January 2021 in “Skin appendage disorders”

Trichodynia is a painful scalp condition not directly linked to the amount or type of hair loss and may involve psychological factors, with treatments showing mixed results.

research A Neuroendocrinological Perspective on Human Hair Follicle Pigmentation

56 citations, November 2010 in “Pigment Cell & Melanoma Research”

Brain hormones significantly affect hair color and could potentially be used to prevent or reverse grey hair.

research Human Hair Follicle: An Update on Biology and Perspectives in Hair Growth Disorders Treatment

2 citations, January 2014 in “Hair therapy & transplantation”

New treatments for hair growth disorders are needed due to limited current options and complex hair follicle biology.

research Role of Insulin Resistance and Diet in Acne

39 citations, January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

Eating high glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

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community He used Dutasteride for 20 years. Interview

in Treatment 113 upvotes 3 months ago

Dutasteride has been used for 20 years with some hair thickness improvement but no dramatic regrowth. The user also experimented with minoxidil, tretinoin, and peptides like BPC 157 for potential benefits in hair density and quality.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 137 upvotes 7 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 864 upvotes 4 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 73 upvotes 7 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.