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Glossary Substance P

neuropeptide involved in pain perception and inflammation

Substance P (SP) is a neuropeptide that functions as a neurotransmitter and neuromodulator, playing a key role in pain perception by transmitting pain signals to the central nervous system. It is also involved in inflammatory processes and can influence hair growth by affecting the local immune response and blood flow in the scalp.

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Research

5 / 1000+ results

research Stress Inhibits Hair Growth in Mice by Induction of Premature Catagen Development and Deleterious Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways

194 citations , March 2003 in “American Journal of Pathology”

This study found that psychoemotional stress disrupts hair growth in mice by terminating anagen and suggests a potential pathway for pharmacological management of stress-related hair loss in humans.

research Indications for a brain‐hair follicle axis: inhibition of keratinocyte proliferation and up‐regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P

125 citations , September 2001 in “The FASEB Journal”

This study demonstrated that stress inhibited hair growth in mice, likely through substance P-dependent activation of immune cells, highlighting a brain-hair follicle connection.

research Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice

76 citations , April 2013 in “PLoS ONE”

The researchers reported that reactive oxygen species regulate the stress-induced SP-Mast cell pathway, which might support using antioxidants to treat stress-related hair loss.

research Influence of substance-P on cultured sebocytes

46 citations , April 2008 in “Archives of Dermatological Research”

This study found that substance P may be involved in the pathogenesis of acne by increasing the expression of certain cytokines and receptors in cultured sebocytes.

research Tumour Necrosis Factor Alpha, Interferon Gamma and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin

24 citations , April 2013 in “PLOS ONE”

This study identifies substance P, TNFα, and IFNγ as novel regulators of prolactin and its receptor expression in human skin, suggesting intracutaneous prolactin is not controlled by dopamine.

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Community Join

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community PP405 Updates Feel Like Breadcrumbs at This Point

11 upvotes 4 months ago

PP405 updates are seen as vague and lacking substance, causing frustration among users. Some users report positive effects from using minoxidil and dutasteride, while others remain skeptical about new treatments.

community The perfect reverse reverse hair-loss nuclear stack for those who feel left out

in Satire 415 upvotes 1 year ago

A satirical discussion on intentionally inducing hair loss using harmful habits and substances like cigarettes, junk food, anabolic steroids, and stress. The conversation humorously suggests extreme measures like chemotherapy and hydrofluoric acid, while also mentioning the ineffectiveness of sulfates and pumpkin seed oil in hair loss prevention.

community Targeting multiple AGA mechanisms with commonly available substances

4 upvotes 7 years ago

The conversation discusses using a multimodal approach to treat androgenic alopecia, including substances like gamma-linolenic acid, DHA, sulforaphane, melatonin, cetirizine, astaxanthin, fisetin, apigenin, curcumin, limonene, genistein, and berberine. Users also mention using ketoconazole, minoxidil, and low-level laser therapy (LLLT) as part of their hair loss treatment regimens.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 413 upvotes 1 year ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community RU58841 Permanently Fixed Balding In Unexpected Way.

in Satire 123 upvotes 10 months ago

The user humorously describes trying various hair loss treatments, including minoxidil, finasteride, and RU58841, with a satirical twist involving psychedelic experiences and imaginary entities. They mistakenly used LSD instead of RU58841 and plan to continue experimenting with other substances.

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Learn

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learn GHK-Cu

Copper peptide used in skin and hair cosmetics

How to judge a GHK-Cu product No GHK-Cu product has published human trial evidence for hair loss, so none can be ranked on efficacy; products differ in purity, stability and third-party testing. The FDA lists injectable GHK-Cu among compounding substances that may present significant safety risks (immunogenicity, impurities, limited human data).
GHK-Cu: Does it have side effects or is it completely safe? For topical cosmetic use, one 24-hour study in cultured skin cells found a low potential for irritation, but no clinical trial has characterised its side effects on the scalp. Injected or oral GHK-Cu has no published human safety data, and the FDA lists injectable GHK-Cu among compounding substances that may present significant safety risks.

learn Dexpanthenol

Provitamin B5, a moisturiser in hair and skin products

learn Mesotherapy

Injections of drug or vitamin mixtures into the scalp

learn Thymosin Beta 4

learn Neem Oil

Oil from the neem tree, used in traditional remedies

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