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    Glossary Substance P

    neuropeptide involved in pain perception and inflammation

    Substance P (SP) is a neuropeptide that functions as a neurotransmitter and neuromodulator, playing a key role in pain perception by transmitting pain signals to the central nervous system. It is also involved in inflammatory processes and can influence hair growth by affecting the local immune response and blood flow in the scalp.

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    Research 10 of 1000+

    1. Stress Inhibits Hair Growth in Mice by Induction of Premature Catagen Development and Deleterious Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways American Journal of Pathology · 2003 · 194 citations
    2. Indications for a brain‐hair follicle axis: inhibition of keratinocyte proliferation and up‐regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P The FASEB Journal · 2001 · 125 citations
    3. Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice PLoS ONE · 2013 · 76 citations
    4. Influence of substance-P on cultured sebocytes Archives of Dermatological Research · 2008 · 46 citations
    5. Tumour Necrosis Factor Alpha, Interferon Gamma and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin PLOS ONE · 2013 · 24 citations
    6. New effects of caffeine on corticotropin‐releasing hormone (CRH)‐induced stress along the intrafollicular classical hypothalamic–pituitary–adrenal (HPA) axis (CRH‐R1/2, IP<sub>3</sub>‐R, ACTH, MC‐R2) and the neurogenic non‐HPA axis (substance P, p75<sup>NTR</sup>and TrkA) in<i>ex vivo</i>human male androgenetic scalp hair follicles British Journal of Dermatology · 2020 · 12 citations
    7. Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P–induced human mast cell activation and degranulation in the hair follicle The Journal of Allergy and Clinical Immunology · 2018 · 8 citations
    8. Substance P prolongs human hair growth in vitro Journal of dermatological science · 2003 · 8 citations
    9. Substance P in keratosis follicularis spinulosa decalvans JAAD case reports · 2015 · 4 citations
    10. Effects of Guasha on histomorphology of scraped skins and on expression of calcitonin gene-related peptide and substance P in rats Deleted Journal · 2018 · 3 citations
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    Community 10 of 17

    1. Targeting multiple AGA mechanisms with commonly available substances Reddit · 4 Feb 2019
    2. For sublingual minoxidil users and topical minoxidil drinkers : You should STOP spraying topical minoxidil to your mouth NOW. You should consider stopping using a drop of it and mixing it with some other substance too, as you may mess up the dosage Community · 24 Nov 2025
    3. Neck tension, and hair loss, I am 100 percent sure that there is a connection Reddit · 14 May 2024
    4. Soundwaves & Electricity Grows Hair? | Peptide Delivery Model. Reddit · 6 Aug 2024
    5. 2024 vs today. Dutasteride 0.5mg and 5mg oral minoxidil Reddit · 19 Mar 2026
    6. PP405 Updates Feel Like Breadcrumbs at This Point Reddit · 24 May 2026
    7. The perfect reverse reverse hair-loss nuclear stack for those who feel left out Reddit · 21 Jul 2025
    8. Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens Community · 6 Dec 2024
    9. RU58841 Permanently Fixed Balding In Unexpected Way. Reddit · 4 Nov 2025
    10. KwRx 🕊️ on YouTube is teasing an upcoming promising new 'regrowth' treatment Reddit · 29 May 2026
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    Learn 5

    1. Dexpanthenol Provitamin B5, a moisturiser in hair and skin products
    2. GHK-Cu Copper peptide used in skin and hair cosmetics
    3. Mesotherapy Injections of drug or vitamin mixtures into the scalp
    4. Thymosin Beta 4
    5. Neem Oil Oil from the neem tree, used in traditional remedies