Dexpanthenol
Dexpanthenol, also known as D-panthenol, or provitamin B5, is a chemical substance derived from pantothenic acid, a B-complex vitamin. It is widely used for dietary supplements and in pharmaceutical and cosmetic products. Historically, it has been recognized for its role in skin and wound healing, and only recently has its potential benefits for treating hair loss become the subject of scientific inquiry.
Dexpanthenol shows promise in promoting hair growth by enhancing cell proliferation, reducing aging and apoptosis markers, and stimulating the anagen phase while preventing the transition to the catagen phase. It achieves this by positively influencing the behavior of both dermal papilla cells and outer root sheath cells, crucial components in the hair growth cycle. D-panthenol also increases VEGF and its receptor expression, which are key factors in hair follicle health and function.
Research on dexpanthenol's effectiveness in treating hair loss is emerging, with studies indicating positive outcomes. For instance, a study analyzed the use of dexpanthenol as a treatment for male androgenetic alopecia in nine patients. After two months of weekly intramuscular administration of 500mg dexpanthenol, a majority of the patients reported perceived improvements in hair growth. Another study focusing on female pattern hair loss reported high patient satisfaction rates with weekly intramuscular injections of dexpanthenol, noting improvements in hair growth and quality without significant side effects. These findings suggest dexpanthenol's potential as a novel treatment option for different forms of alopecia.
Research
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research Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells
research Dexpanthenol May Be a Novel Treatment for Male Androgenetic Alopecia: Analysis of Nine Cases
research Systemic Dexpanthenol as a Novel Treatment for Female Pattern Hair Loss
research Sulforaphane, L-Menthol, and Dexpanthenol as a Novel Active Cosmetic Ingredient Composition for Relieving Hair Loss Symptoms
research Simultaneous Quantification of Dexpanthenol and Resorcinol from Hair Care Formulation Using Liquid Chromatography: Method Development and Validation
research Efficacy of Intramuscular Injections of Biotin and Dexpanthenol in the Treatment of Diffuse Hair Loss: A Randomized, Double-Blind Controlled Study Comparing Two Brands
research The Antiepileptic and Antidepressant-Like Effects of Dexpanthenol in Female Swiss Albino Mice
research Innovative Method for the Analysis of Dexpanthenol in Hair Care Products
research A Study on the Effectiveness of Dexpanthenol Dermal Spray for Skin Recovery After Laser Hair Removal in the Groin and Intimate Area
research Post-Treatment of Microneedling with a Dexpanthenol-Containing Ointment Accelerates Epidermal Wound Healing in Human 3D Skin Models
research Leveraging Multifaceted Polyphenol Interactions: An Approach for Hair Loss Mitigation
research Evaluation of the Active Ingredient Complex of an Anti-Hair Loss Shampoo on the Activation of Wnt/β-Catenin Pathway in Human Hair Follicle Dermal Papilla Cells
research Evaluation of Anti-Hair Loss Shampoo Through In Vitro Activity in Human Hair Follicle Dermal Papilla Cells and Sensorial Study
research ERALOP Study: Post Adjuvant FEC-Docetaxel Chemotherapy for Early Breast Cancer: Hair Regrowth in Real Life
research Simultaneous Analysis of Active Ingredients in Hair Nourisher Using HPLC
research Analytical Methods on the Determination of Active Ingredients for Hair Nourisher Products
research mTORC1 Activity Controls Human Scalp Hair Follicle Pigmentation and Growth
research Hair Growth Properties of Cinchona Succirubra Extract, Leontopodium Alpinum Extract, and Manganese PCA in Human Hair Follicle Dermal Papilla Cells
research RF-Mesotherapy With Dutasteride: A Future Alternative Treatment for Androgenetic Alopecia
