Leveraging Multifaceted Polyphenol Interactions: An Approach for Hair Loss Mitigation

January 2025 in “ Advanced Materials Interfaces ”

Eunu Kim, Geunsik Lee, Haeshin Lee

tannic acid minoxidil salicylic acid niacinamide dexpanthenol keratin SCANDAL X-ray photoelectron spectroscopy transmission electron microscopy Rogaine

From the encyclopedia

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Salicylic acid →

Niacinamide →

Studysummary This study observed that tannic acid significantly reduced hair shedding by 56.2% over seven days in human participants when used as a coating for controlled release of active compounds to hair follicles.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study examines the potential of tannic acid as a delivery system for SCANDAL molecules (salicylic acid, niacinamide, and dexpanthenol) to reduce hair loss. Tannic acid binds to hair keratin, forming a coating that allows for the controlled release of these molecules, enhancing their efficacy. In a trial with 12 participants, the use of a tannic acid/SCANDAL shampoo led to an average reduction of 56.2% in hair shedding over seven days. While the results are promising, the small sample size limits the generalizability, and future research with a larger cohort is needed.

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