Leveraging Multifaceted Polyphenol Interactions: An Approach for Hair Loss Mitigation

This study investigates tannic acid as a novel treatment for hair loss, offering a safer alternative to traditional methods like minoxidil. Tannic acid acts as an adhesion mediator, binding to hair keratin and serving as a reservoir for active molecules (salicylic acid, niacinamide, and dexpanthenol, collectively termed SCANDAL). It forms a stable coating on hair, allowing for the controlled release of these molecules upon moisture exposure, directly benefiting hair follicles. In a seven-day study with 12 participants, there was an average reduction of 56.2% in shed hairs. The presence and effectiveness of tannic acid were confirmed using X-ray photoelectron spectroscopy and transmission electron microscopy, highlighting its potential in enhancing hair health and mitigating hair loss.