Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells

    January 2016 in “ Annals of Dermatology ”
    Shanghun Shin, Karam Kim, Myung J. Lee, Jeong-Ju Lee, Sung-Jin Choi, Kyung-Suk Kim, Jin Hwan Ko, Hyunjoo Han, Su Young Kim, Hae Jeong Youn, Kyu Joong Ahn, In-Sook An, Sungkwan An, Hwa Jun
    Image of study
    TLDR Green tea component EGCG may help prevent hair loss by changing microRNA levels in certain scalp cells.
    In the 2016 study, researchers explored how epigallocatechin gallate (EGCG), a green tea component, affects human dermal papilla cells (DPCs) exposed to 5α-dihydrotestosterone (DHT), a hormone linked to androgenic alopecia. They discovered that EGCG could prevent DHT-induced cell death, lower intracellular reactive oxygen species (ROS) levels, and reduce cellular senescence. The study identified significant changes in the expression of 53 microRNAs (miRNAs) due to EGCG treatment, which are crucial in cell processes like anti-oxidation, apoptosis, proliferation, aging, and cell cycle regulation. These findings suggest that EGCG may counteract the adverse effects of DHT on hair follicles by modulating miRNA expression, potentially offering a new treatment strategy for androgenic alopecia. The research was funded by the KU Research Professor Program of Konkuk University, the Ministry of Science, ICT and Future Planning, and the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea.
    Discuss this study in the Community →

    Research cited in this study

    15 / 15 results

    Related Community Posts Join

    5 / 5 results

      community Natural Remedies: Polyphenols and Hair Loss

       19 upvotes 6 years ago
      Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

      community My stack and 9 months progress (Nov, 2024 to July, 2025)

      in Is this regrowth?  33 upvotes 7 months ago
      The user shared their hair regrowth progress using a regimen including omega-3, flaxseed, EGCG, green tea, zinc, copper, probiotics, microneedling, topical finasteride, and minoxidil. Other users expressed skepticism about the effectiveness of the regimen, suggesting more proven treatments or considering a hair transplant.

      community This serum outperformed Minoxidil in a recent study. Please debunk

       23 upvotes 6 years ago
      A topical solution called "Multi-Peptide Serum for Hair Density" by The Ordinary Company, which contains several ingredients that are used in alternatives to Minoxidil and was found to have better results than 5% Minoxidil in a study. People who have tried it shared their experiences with the serum as well.

    Related Research

    2 / 2 results