TLDR UVB radiation changes the levels of certain microRNAs in skin cells, which may affect cell survival and hair growth.
In the 2014 study, researchers found that UVB radiation at doses of ≥50 mJ/cm² caused significant cytotoxicity and apoptosis in normal human dermal papilla cells (nHDPs), which are crucial for hair follicle growth, as well as increased reactive oxygen species (ROS) generation. They identified 42 microRNAs (miRNAs) with significantly altered expression profiles after UVB exposure, with 35 being upregulated and 7 downregulated. These miRNAs are thought to be involved in cell survival and death-related functions, suggesting that miRNA-based cellular mechanisms may contribute to the UVB-induced cellular response in nHDPs.
53 citations,
January 2009 in “Journal of Investigative Dermatology” UVB radiation harms hair growth and health, causing cell death and other changes in human hair follicles.
62 citations,
January 2003 in “Dermatology” Sunlight worsens hair loss; protect scalp.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” Researchers developed a method to grow human hair follicles using 3D-printed skin models and modified cells.
15 citations,
April 2014 in “Experimental Dermatology” Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.
41 citations,
June 2013 in “PLOS ONE” Engineered skin substitutes can grow hair but have limitations like missing sebaceous glands and hair not breaking through the skin naturally.
314 citations,
April 2010 in “Developmental Cell” β-catenin in the dermal papilla is crucial for normal hair growth and repair.
56 citations,
July 2005 in “Experimental Dermatology” Injected human hair follicle cells can create new, small hair follicles in skin cultures.
