Tissue Engineered Human Hair Follicles from Genetically, Environmentally, and Extrinsically Reprogrammed Dermal Papilla Cells

    April 2017 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Abigail Coffman, Hasan Erbil Abaci, J.C. Chen, E. Wang, Y. Doucet, Zongyou Guo, Angela M. Christiano
    TLDR Researchers developed a method to grow human hair follicles using 3D-printed skin models and modified cells.
    Researchers developed a tissue engineering strategy using 3D-printing technology to create hair follicle-like microchannels on human skin equivalents (HSEs), allowing dermal papilla cells (DPs) to form 3D spheroids and initiate epidermal-mesenchymal interactions. By overexpressing Lef-1, a master regulator of the inductive DP gene signature, they significantly promoted hair follicle differentiation. Prolonged culture of these constructs resulted in well-defined hair follicle layers and hair fiber growth. Additionally, they enhanced hair follicle induction by testing various exogenous small molecules targeting Wnt and Jak-STAT signaling. This method showed potential for regenerating entire hair follicles from cultured human cells, which could significantly impact the medical management of patients with significant skin loss.
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