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GlossaryLymphoid Enhancer-Binding Factor 1 (Lef-1)

protein regulating gene expression in immune cells and hair follicles

Lymphoid Enhancer-Binding Factor 1 (LEF1) is a protein that plays a crucial role in the regulation of gene expression, particularly in the development and function of immune cells and hair follicles. It is part of the Wnt signaling pathway, which is important for cell growth, differentiation, and tissue regeneration. In the context of hair biology, LEF1 is involved in the formation and cycling of hair follicles, and its dysregulation can contribute to conditions like alopecia.

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Randomized Trial of Electrodynamic Microneedling Combined with 5% Minoxidil Topical Solution for Treating Androgenetic Alopecia in Chinese Males and Molecular Mechanistic Study of the Involvement of the Wnt/β-Catenin Signaling Pathway

research Randomized Trial of Electrodynamic Microneedling Combined with 5% Minoxidil Topical Solution for Treating Androgenetic Alopecia in Chinese Males and Molecular Mechanistic Study of the Involvement of the Wnt/β-Catenin Signaling Pathway

10 citations , May 2020 in “Journal of Dermatological Treatment”

Microneedling with 5% minoxidil improves hair loss in Chinese men by activating Wnt/ß-catenin pathway.

research Regulation of a Hair Follicle Keratin Intermediate Filament Gene Promoter

39 citations , December 1998 in “Journal of Cell Science”

The LEF-1 binding site enhances gene expression in hair follicles, with other proteins aiding specific regulation.

research Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development

318 citations , October 1998 in “The Journal of Cell Biology”

Keratin 17 is important for skin development and may help define skin cell types.

research Tissue Engineered Human Hair Follicles from Genetically, Environmentally, and Extrinsically Reprogrammed Dermal Papilla Cells

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Researchers developed a method to grow human hair follicles using 3D-printed skin models and modified cells.

research The Metabolites of Bifidobacterium Longum BB536 Alleviate DHT-Damaged Human Dermal Papilla Cells by Activating WNT/β-Catenin Signaling

August 2024 in “Food Bioscience”

Bifidobacterium longum BB536 metabolites may help treat hair loss by repairing and promoting hair cell growth.

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community HairClone developing cell replacement treatments for Hair Loss

6 upvotes 7 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

community April 21, 2022 to December 7, 2023 [Fin+Min+Stamp]

in Progress Pictures 358 upvotes 2 years ago

A user shared progress pictures showing hair regrowth from April 21, 2022, to December 7, 2023, using finasteride, minoxidil, and a derma stamp. They switched from foam to liquid minoxidil and believe the results improved.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 680 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.