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GlossaryLymphoid Enhancer-Binding Factor 1 (Lef-1)

protein regulating gene expression in immune cells and hair follicles

Lymphoid Enhancer-Binding Factor 1 (LEF1) is a protein that plays a crucial role in the regulation of gene expression, particularly in the development and function of immune cells and hair follicles. It is part of the Wnt signaling pathway, which is important for cell growth, differentiation, and tissue regeneration. In the context of hair biology, LEF1 is involved in the formation and cycling of hair follicles, and its dysregulation can contribute to conditions like alopecia.

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research Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach

184 citations, December 2018 in “Nature Communications”

Researchers created human hair follicles using a new method that could help treat hair loss.

research The Inductive Effect of Ginsenoside F2 on Hair Growth by Altering the WNT Signal Pathway in Telogen Mouse Skin

42 citations, March 2014 in “European Journal of Pharmacology”

Ginsenoside F2 from ginseng may increase hair growth better than standard treatments by affecting cell growth signals.

Randomized Trial of Electrodynamic Microneedling Combined with 5% Minoxidil Topical Solution for Treating Androgenetic Alopecia in Chinese Males and Molecular Mechanistic Study of the Involvement of the Wnt/β-Catenin Signaling Pathway

research Randomized Trial of Electrodynamic Microneedling Combined with 5% Minoxidil Topical Solution for Treating Androgenetic Alopecia in Chinese Males and Molecular Mechanistic Study of the Involvement of the Wnt/β-Catenin Signaling Pathway

10 citations, May 2020 in “Journal of Dermatological Treatment”

Microneedling with 5% minoxidil improves hair loss in Chinese men by activating Wnt/ß-catenin pathway.

research A Novel Secretory Vesicle from Deer Antlerogenic Mesenchymal Stem Cell-Conditioned Media Promotes Tissue Regeneration

9 citations, January 2018 in “Stem Cells International”

Deer antler stem cell fluid helps regenerate tissue better than fat-derived stem cell fluid.

research Hair Growth-Promoting Effects of Sargassum Glaucescens Oligosaccharides Extracts

8 citations, March 2022 in “Journal of The Taiwan Institute of Chemical Engineers”

Extracts from a type of brown seaweed can help promote hair growth.

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Community Join

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community HairClone developing cell replacement treatments for Hair Loss

6 upvotes 5 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

community April 21, 2022 to December 7, 2023 [Fin+Min+Stamp]

in Progress Pictures 358 upvotes 11 months ago

A user shared progress pictures showing hair regrowth from April 21, 2022, to December 7, 2023, using finasteride, minoxidil, and a derma stamp. They switched from foam to liquid minoxidil and believe the results improved.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 1 month ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.