Reorganization of Hair Follicles in Human Skin Organ Culture Induced by Cultured Human Follicle-Derived Cells
July 2005
in “
Experimental Dermatology
”
hair follicle-derived cells hair follicle reorganization human skin organ culture velus-like hair growth miniaturized hair follicles sebaceous glands hair follicle generation hair follicle development hair follicle differentiation cell therapy hair loss hair cells hair reorganization skin culture vellus hair small hair follicles oil glands hair growth hair development hair differentiation cell treatment baldness
TLDR Injected human hair follicle cells can create new, small hair follicles in skin cultures.
In 2005, Krugluger et al. conducted a study using skin specimens from five male patients to investigate the ability of human hair follicle-derived cells to induce hair follicle reorganization in a human skin organ culture system. The cells, isolated from patients undergoing hair restoration surgery, were expanded in vitro and injected into the skin specimens. After 4 weeks, velus-like hair growth was observed, and after 8 weeks, multiple miniaturized hair follicles with sebaceous glands were present, suggesting that the reorganized hair follicles were formed de novo from the injected cells. The study demonstrated that human skin organ culture could support hair follicle generation and that the system could be used to study human hair follicle development and differentiation, potentially aiding in cell therapy approaches for hair loss.
