Dermal-Epidermal Interactions in Hair Follicle Development and Maintenance

October 1996 in “ Dermatologic clinics ”

Colin A.B. Jahoda, Amanda J. Reynolds

androgenetic steroid hormones autoimmune attacks on hair follicles chemotherapy alopecia in vitro models laboratory animal models steroid hormones autoimmune hair loss hair loss due to chemotherapy hair loss lab models

TLDR Hair loss is mainly caused by hormones, autoimmune issues, and chemotherapy, and needs more research for treatments.

The document discussed the critical role of dermal-epidermal interactions in hair follicle development and maintenance. It highlighted that dermal papilla cells, derived from fibroblast-like cells, are essential for hair growth control. Experiments demonstrated that cultured dermal papilla cells could induce hair regeneration when reimplanted into amputated follicles. Co-culturing dermal papilla cells with epidermal cells provided insights into their inductive properties. Additionally, germinative epidermal cells, isolated from rodent and human follicles, significantly influenced follicle formation when combined with dermal sheath cells. The ability to culture and reconstruct hair follicles in vitro was also explored, emphasizing the universal nature of dermal-epidermal interactions across different species. The study concluded that understanding these interactions could unlock broader biological mysteries and advance hair growth research.

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Research cited in this study

4 / 4 results

research Dynamic Expression Patterns of Tenascin, Proteoglycans, and Cell Adhesion Molecules During Human Hair Follicle Morphogenesis

67 citations, February 1994 in “Developmental dynamics”

Specific proteins and molecules play key roles in the development of human hair follicles.

research Cellular and Extracellular Involvement in the Regeneration of the Rat Lower Vibrissa Follicle

39 citations, April 1992 in “Development”

Both cell and non-cell parts are important for rat whisker follicle regrowth.

research The Secret Life of the Hair Follicle

745 citations, February 1992 in “Trends in genetics”

Hair follicles create different cell layers and proteins, controlled by various molecules.

research Growth of the Hair

521 citations, January 1954 in “Physiological Reviews”

Hair growth is cyclic and influenced mainly by local factors.

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