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Glossary Cytotoxicity

quality of being toxic to cells, often used in cancer treatment

Cytotoxicity refers to the quality of being toxic to cells. It describes the ability of certain substances or treatments, such as chemotherapy drugs, to kill or damage cells. This property is crucial in cancer treatment, where the goal is to target and destroy cancerous cells while minimizing harm to healthy cells.

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research Combinatorial Therapy of Letrozole- and Quercetin-Loaded Spanlastics for Enhanced Cytotoxicity against MCF-7 Breast Cancer Cells

39 citations , August 2022 in “Pharmaceutics”

This study found that the combination of letrozole and quercetin loaded in spanlastics showed enhanced cytotoxicity and other anticancer effects against MCF-7 breast cancer cells compared to individual treatments.

research Encapsulation of Curcumin in Polystyrene-Based Nanoparticles—Drug Loading Capacity and Cytotoxicity

21 citations , April 2021 in “ACS omega”

In this study, curcumin was efficiently loaded into PS–PAA nanoparticles at the formation stage, showing even distribution at low concentrations and good biocompatibility with human skin fibroblasts.

research Cytotoxicity and Collagen Expression Effects of Tideglusib Administration on Human Periodontal Cells: An In-Vitro Study

10 citations , May 2020 in “Clinical and Experimental Health Sciences”

This study found that Tideglusib at 50nM stimulated Type-I collagen production in human gingival fibroblasts and osteoblasts, suggesting potential benefits for bone regeneration.

research Cytotoxicity and Genotoxicity of Tridax procumbens L. in Allium cepa

4 citations , November 2015 in “Research Journal of Medicinal Plant”

This study found that ethanolic, aqueous, and hydroethanolic extracts of Tridax procumbens inhibited mitosis and caused mutagenic effects on cell division in Allium cepa root meristematic cells.

research Cytotoxicity of bendamustine, alone and in combination with novel agents, toward adult T-cell leukemia cells

2 citations , September 2024 in “PLoS ONE”

This study suggests that combining bendamustine with tucidinostat may improve survival in patients with relapsed or refractory adult T-cell leukemia/lymphoma, highlighting its potential for clinical investigation.

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