Potential Targets in the Discovery of New Hair Growth Promoters for Androgenic Alopecia

    Ruchy Jain, Wanchai De-Eknamkul
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    TLDR The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.
    The 2014 study "Potential targets in the discovery of new hair growth promoters for androgenic alopecia" focused on androgenic alopecia (AGA), a common hair loss condition caused by the androgens testosterone and 5α-dihydrotestosterone (5α-DHT). The study identified three potential therapeutic targets for AGA: 5α-reductase, the androgen receptor, and growth-factor-producing genes related to hair growth. At the time, only two FDA-approved drugs, minoxidil and finasteride, were available for AGA treatment, with success rates of 35% and 48% respectively. The researchers suggested that a combination of treatments targeting these areas could lead to more effective AGA treatments in the future. They also explored various compounds with anti-androgenic properties and hair growth promoting activities, suggesting these substances could be potential targets for new treatments.
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