4-(Alkylthio)- and 4-(Arylthio)-Benzonitrile Derivatives as Androgen Receptor Antagonists for the Topical Suppression of Sebum Production

    March 2009 in “ Bioorganic & Medicinal Chemistry Letters ”
    Lorna Helen Mitchell, Zhi Wang, Lain-Yen Hu … Kimberly Jane Wade
    Studysummary This study reports that 4-(alkylthio)- and 4-(arylthio)-benzonitriles showed moderate sebum reduction as androgen receptor antagonists when applied topically in a validated animal model.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 4

    1. (1R,2S)-4-(2-Cyano-Cyclohexyl-Oxy)-2-Trifluoromethyl-Benzonitrile, A Potent Androgen Receptor Antagonist For Stimulating Hair Growth And Reducing Sebum Production Bioorganic & Medicinal Chemistry Letters · 2007
    2. Preparation of 4-Aryl-2-Trifluoromethylbenzonitrile Derivatives as Androgen Receptor Antagonists for Topical Suppression of Sebum Production Bioorganic & Medicinal Chemistry Letters · 2007
    3. Synthesis and Biological Evaluation of Amino-Pyridines as Androgen Receptor Antagonists for Stimulating Hair Growth and Reducing Sebum Production Bioorganic & Medicinal Chemistry Letters · 2007
    4. Treatment of Androgenic Disorders in Women: Acne, Hirsutism, and Alopecia Cleveland Clinic journal of medicine · 1990

    Related research 5

    1. Diphenyl Ethers as Androgen Receptor Antagonists for the Topical Suppression of Sebum Production Bioorganic & Medicinal Chemistry Letters · 2009
    2. Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications Journal of medicinal chemistry · 2008
    3. (1R,2S)-4-(2-Cyano-Cyclohexyl-Oxy)-2-Trifluoromethyl-Benzonitrile, A Potent Androgen Receptor Antagonist For Stimulating Hair Growth And Reducing Sebum Production Bioorganic & Medicinal Chemistry Letters · 2007
    4. Preparation of 4-Aryl-2-Trifluoromethylbenzonitrile Derivatives as Androgen Receptor Antagonists for Topical Suppression of Sebum Production Bioorganic & Medicinal Chemistry Letters · 2007
    5. Synthesis and Biological Evaluation of Amino-Pyridines as Androgen Receptor Antagonists for Stimulating Hair Growth and Reducing Sebum Production Bioorganic & Medicinal Chemistry Letters · 2007