TLDR A compound made by Pfizer can potentially stimulate hair growth and reduce oil production, making it a good candidate for topical use.
In 2007, Pfizer Global Research and Development synthesized and evaluated a series of amino-pyridines for their androgen antagonist activities. The most potent compound, (R)-(+)-6-[methyl-(1-phenyl-ethyl)-amino]-4-trifluoromethyl-nicotinonitrile, showed significant potential for stimulating hair growth and reducing sebum production. This was tested on two animal models: 10 male C3H/HeN mice and 5 male Syrian hamsters. The mice were treated twice daily for 4 weeks, and the hamsters were treated twice daily for 2 weeks. The compound was also found to be rapidly metabolized in rat, dog, and human hepatocytes, indicating favorable pharmacokinetic characteristics for a topical agent. The study concluded that this compound had remarkable in vivo activity for both stimulating hair growth and reducing sebum production, making it a promising candidate for topical applications.
Cited in this study
4 / 4 results
research Acne
81 citations
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January 2002 in “American journal of clinical dermatology” Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.
204 citations
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February 2000 in “Current Medicinal Chemistry” Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.
62 citations
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May 1997 in “Journal of Pharmaceutical Sciences” Sebaceous glands in the skin play a key role in absorbing the antiandrogen drug RU 58841, especially when it's encapsulated in liposomes.
19 citations
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July 1990 in “Cleveland Clinic journal of medicine” Androgen excess disorders in women were effectively treated with spironolactone, estrogen, and dexamethasone.
7 citations
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April 2009 in “Bioorganic & Medicinal Chemistry Letters” Diphenyl ethers can potentially reduce excess oil production when applied on the skin, helping treat conditions like acne.
14 citations
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November 2007 in “Bioorganic & Medicinal Chemistry Letters” The compound (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile can stimulate hair growth and reduce oil production when applied topically.
17 citations
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October 2007 in “Bioorganic & Medicinal Chemistry Letters” A compound made by Pfizer can potentially stimulate hair growth and reduce oil production, making it a good candidate for topical use.
