Synthesis and Biological Evaluation of Amino-Pyridines as Androgen Receptor Antagonists for Stimulating Hair Growth and Reducing Sebum Production

    August 2007 in “ Bioorganic & Medicinal Chemistry Letters ”
    Lain-Yen Hu, Huangshu John Lei, Daniel K. Du … Howard G. Welgus
    Studysummary This study found that a specific amino-pyridine compound showed potent androgen receptor antagonist activity, stimulating hair growth in mice and reducing sebum production in a hamster model.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 4

    1. Acne American journal of clinical dermatology · 2002
    2. Androgen Receptor Antagonists Structure-Activity Relationships Current Medicinal Chemistry · 2000
    3. Importance of Sebaceous Glands in Cutaneous Penetration of an Antiandrogen: Target Effect of Liposomes Journal of Pharmaceutical Sciences · 1997
    4. Treatment of Androgenic Disorders in Women: Acne, Hirsutism, and Alopecia Cleveland Clinic journal of medicine · 1990

    Related research 3

    1. Diphenyl Ethers as Androgen Receptor Antagonists for the Topical Suppression of Sebum Production Bioorganic & Medicinal Chemistry Letters · 2009
    2. (1R,2S)-4-(2-Cyano-Cyclohexyl-Oxy)-2-Trifluoromethyl-Benzonitrile, A Potent Androgen Receptor Antagonist For Stimulating Hair Growth And Reducing Sebum Production Bioorganic & Medicinal Chemistry Letters · 2007
    3. Synthesis and Biological Evaluation of Amino-Pyridines as Androgen Receptor Antagonists for Stimulating Hair Growth and Reducing Sebum Production Bioorganic & Medicinal Chemistry Letters · 2007