TLDR A compound made by Pfizer can potentially stimulate hair growth and reduce oil production, making it a good candidate for topical use.
In 2007, Pfizer Global Research and Development synthesized and evaluated a series of amino-pyridines for their androgen antagonist activities. The most potent compound, (R)-(+)-6-[methyl-(1-phenyl-ethyl)-amino]-4-trifluoromethyl-nicotinonitrile, showed significant potential for stimulating hair growth and reducing sebum production. This was tested on two animal models: 10 male C3H/HeN mice and 5 male Syrian hamsters. The mice were treated twice daily for 4 weeks, and the hamsters were treated twice daily for 2 weeks. The compound was also found to be rapidly metabolized in rat, dog, and human hepatocytes, indicating favorable pharmacokinetic characteristics for a topical agent. The study concluded that this compound had remarkable in vivo activity for both stimulating hair growth and reducing sebum production, making it a promising candidate for topical applications.
research Acne
81 citations,
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17 citations,
August 2007 in “Bioorganic & Medicinal Chemistry Letters” A compound made by Pfizer can potentially stimulate hair growth and reduce oil production, making it a good candidate for topical use.
