14 citations,
August 2007 in “Bioorganic & Medicinal Chemistry Letters”
The compound (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile can stimulate hair growth and reduce oil production when applied topically.
The user discusses using Minoxidil for hair loss and is considering RU58841 to reduce excessive oil production. They seek advice on RU58841's effectiveness in blocking sebumproduction.
The conversation discusses using scalp antiandrogens like RU58841, pyrilutamide, or fluridil on the face to reduce sebumproduction, noting that clascoterone (winlevi) is an approved facial antiandrogen with underwhelming reviews.
Dutasteride can drastically reduce sebumproduction, leading to dryer hair and shedding. Alternating shampoos and periodic silica supplementation can improve hair quality and thickness.
The user experienced a slight decrease in hair shedding and scalp itch, and reduced sebumproduction using Pyrilutamide, but stopped due to chest pain, breathing difficulties, and heart issues. They felt normal a week after discontinuing and doubted FDA approval for the drug.
Winlevi (clascoterone) is discussed as a treatment for hormonal acne and seborrheic dermatitis due to its ability to block DHT and regulate sebumproduction. The post suggests that Winlevi could offer a novel approach for managing seborrheic dermatitis.