TLDR The compound (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile can stimulate hair growth and reduce oil production when applied topically.
In 2007, a study was conducted on the compound (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, an androgen receptor antagonist, to assess its potential in stimulating hair growth and reducing sebum production. The compound was tested on two animal models: male C3H/HeN mice and male Syrian hamsters, with 10 and 5 animals in each experimental group respectively. The compound was applied topically twice daily for 4 weeks in mice and for 2 weeks in hamsters. The study found that the compound demonstrated significant potency in stimulating hair growth and reducing sebum production. It also showed reversible pharmacology and favorable pharmacokinetic characteristics for a topical agent. However, the results of metabolic stability tests in rat, dog, and human hepatocytes, as well as pharmacokinetics in male Sprague-Dawley rats and transepidermal delivery through human cadaver skin, were not provided in the document.
Cited in this study
4 / 4 results
research Acne
81 citations
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January 2002 in “American journal of clinical dermatology” Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.
204 citations
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February 2000 in “Current Medicinal Chemistry” Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.
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May 1997 in “Journal of Pharmaceutical Sciences” Sebaceous glands in the skin play a key role in absorbing the antiandrogen drug RU 58841, especially when it's encapsulated in liposomes.
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July 1990 in “Cleveland Clinic journal of medicine” Androgen excess disorders in women were effectively treated with spironolactone, estrogen, and dexamethasone.
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May 2010 in “Journal of Medicinal Chemistry” A new compound was created in 2010 that can control oil production when applied to the skin, and its effects are completely reversible after two weeks.
7 citations
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April 2009 in “Bioorganic & Medicinal Chemistry Letters” Diphenyl ethers can potentially reduce excess oil production when applied on the skin, helping treat conditions like acne.
14 citations
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November 2007 in “Bioorganic & Medicinal Chemistry Letters” The compound (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile can stimulate hair growth and reduce oil production when applied topically.
17 citations
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October 2007 in “Bioorganic & Medicinal Chemistry Letters” A compound made by Pfizer can potentially stimulate hair growth and reduce oil production, making it a good candidate for topical use.
