(1R,2S)-4-(2-Cyano-Cyclohexyl-Oxy)-2-Trifluoromethyl-Benzonitrile, A Potent Androgen Receptor Antagonist For Stimulating Hair Growth And Reducing Sebum Production

    August 2007 in “ Bioorganic & Medicinal Chemistry Letters ”
    Lain-Yen Hu, Daniel K. Du, Jennifer K. Hoffman … Howard G. Welgus
    Studysummary This study reported that the compound (1R, 2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile effectively stimulated hair growth in mice and reduced sebum production in hamsters.
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    Research cited in this study 4

    1. Acne American journal of clinical dermatology · 2002
    2. Androgen Receptor Antagonists Structure-Activity Relationships Current Medicinal Chemistry · 2000
    3. Importance of Sebaceous Glands in Cutaneous Penetration of an Antiandrogen: Target Effect of Liposomes Journal of Pharmaceutical Sciences · 1997
    4. Treatment of Androgenic Disorders in Women: Acne, Hirsutism, and Alopecia Cleveland Clinic journal of medicine · 1990

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