TLDR The compound (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile can stimulate hair growth and reduce oil production when applied topically.
In 2007, a study was conducted on the compound (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, an androgen receptor antagonist, to assess its potential in stimulating hair growth and reducing sebum production. The compound was tested on two animal models: male C3H/HeN mice and male Syrian hamsters, with 10 and 5 animals in each experimental group respectively. The compound was applied topically twice daily for 4 weeks in mice and for 2 weeks in hamsters. The study found that the compound demonstrated significant potency in stimulating hair growth and reducing sebum production. It also showed reversible pharmacology and favorable pharmacokinetic characteristics for a topical agent. However, the results of metabolic stability tests in rat, dog, and human hepatocytes, as well as pharmacokinetics in male Sprague-Dawley rats and transepidermal delivery through human cadaver skin, were not provided in the document.
research Acne
81 citations,
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August 2007 in “Bioorganic & Medicinal Chemistry Letters” The compound (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile can stimulate hair growth and reduce oil production when applied topically.
17 citations,
August 2007 in “Bioorganic & Medicinal Chemistry Letters” A compound made by Pfizer can potentially stimulate hair growth and reduce oil production, making it a good candidate for topical use.
