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    Did you mean Androgen Receptor Antagonists?
    Glossary Androgen Receptor Antagonists

    block male hormones like testosterone from affecting tissues

    Androgen Receptor Antagonists, also known as antiandrogens, are medications that block the action of androgens, which are male sex hormones like testosterone. These drugs work by binding to androgen receptors, preventing androgens from exerting their effects on tissues, and are commonly used in the treatment of conditions like prostate cancer, androgenic alopecia (male-pattern baldness), and certain types of acne.

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    Research 10 of 1000+

    1. Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships Current Medicinal Chemistry · 2000 · 204 citations
    2. Design and synthesis of novel androgen receptor antagonists with sterically bulky icosahedral carboranes Bioorganic & medicinal chemistry · 2005 · 45 citations
    3. Treatment of female pattern hair loss with the androgen receptor antagonist flutamide Australasian Journal of Dermatology · 2011 · 30 citations
    4. Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production Bioorganic & Medicinal Chemistry Letters · 2007 · 17 citations
    5. (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production Bioorganic & Medicinal Chemistry Letters · 2007 · 14 citations
    6. Highly efficient nucleophilic addition of alkyl Grignard reagents to 17-ketosteroids in the presence of cerium(III) chloride: Synthesis of 17α-propyl-17β-hydroxy-4-androsten-3-one, an androgen receptor antagonist Tetrahedron Letters · 1994 · 14 citations
    7. Rational Design of a Topical Androgen Receptor Antagonist for the Suppression of Sebum Production with Properties Suitable for Follicular Delivery Journal of Medicinal Chemistry · 2010 · 11 citations
    8. 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production Bioorganic & Medicinal Chemistry Letters · 2009 · 11 citations
    9. Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production Bioorganic & Medicinal Chemistry Letters · 2007 · 11 citations
    10. Androgens and acne: perspectives on clascoterone, the first topical androgen receptor antagonist Expert opinion on pharmacotherapy · 2021 · 9 citations
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    Community 10 of 345

    1. Anyone know by what percentage Pyrilutamide or Ru decrease your androgens? Reddit · 3 Dec 2024
    2. How is the GT20029 different to pyrilutamide as an androgenic antagonist Reddit · 14 Jan 2025
    3. Is there any role for topical DHT antagonists, or does a 5-AR inhibitor remove the need for them as therapy Reddit · 6 Jan 2025
    4. Pyrilutamide for Hair Loss!? (Ft. Steve Cook) Reddit · 15 May 2026
    5. I’ve been on RU for about 2 months. Is that too short to judge results? Reddit · 14 Nov 2025
    6. EMA is re-examining Winlevi (clascoterone at lower concentration) Reddit · 1 Jul 2025
    7. I ingested RU58841 orally to see if its legit Reddit · 16 May 2025
    8. To everyone who cant use FIN and doesnt want to use RU Reddit · 19 Aug 2024
    9. New Hair Loss Treatment from Kintor Just Hit the Market: KX-826! Reddit · 9 Jul 2024
    10. [30M] 4 Months of Progress Oral 3MgMin&1.1MgFin + .5mm Derma Roller Mondays and Fridays Reddit · 26 Jun 2024
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    Learn 8 of 12

    1. Clascoterone Topical androgen-receptor blocker, approved as an acne cream
    2. Spironolactone Blood-pressure and diuretic drug with anti-androgen effects
    3. GT20029 Experimental topical drug designed to break down androgen receptors
    4. Cyproterone a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
    5. Pyrilutamide Experimental topical anti-androgen, also known as KX-826
    6. Bicalutamide Nonsteroidal anti-androgen, originally a prostate cancer drug
    7. RU58841 Experimental topical anti-androgen sold as a research chemical
    8. Fluridil Topical anti-androgen sold as a cosmetic lotion
    All learn results →