Spironolactone
aka - Aldactone
Where to find Spironolactone
Tracking 2 topical products by companies like Minoxidil Express and MinoxidilMax. View all 2 products »Spironolactone is a versatile medication, traditionally used as a diuretic for treating conditions like hypertension and heart failure, but it also plays a significant role in dermatology and hair loss treatment. Known as a mineralocorticoid receptor antagonist and potassium-sparing diuretic with powerful anti-androgenic properties, it is also used for primary hyperaldosteronism, ascites, acne vulgaris, hirsutism, and female pattern hair loss. For hair loss, spironolactone works by blocking androgen receptors and reducing the production of testosterone and its potent metabolite, dihydrotestosterone (DHT), which are key players in androgenetic alopecia and other conditions influenced by androgens, such as hirsutism and acne.
Research underscores Spironolactone's efficacy, with studies highlighting positive outcomes in treating hirsutism and androgenic alopecia in women, demonstrating improvements in hair density and a reduction in hair shedding with few side effects.
The community reflects a variety of sentiments and experiences with spironolactone, particularly among women tackling hair loss. Members share stories of improved hair health and reduced shedding, often discussing its use in combination with other treatments like minoxidil to enhance outcomes. While many report positive effects, discussions also touch on the importance of monitoring for potential side effects and the need for a tailored approach under medical guidance. Community exchanges underscore spironolactone as a valued option in the broader treatment landscape for hair loss, especially for those seeking alternatives to more conventional therapies.
Research
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research Oral spironolactone therapy for female patients with acne, hirsutism or androgenic alopecia
research Comparison of Spironolactone, Flutamide, and Finasteride Efficacy in the Treatment of Hirsutism: A Randomized, Double Blind, Placebo-Controlled Trial1
research Spironolactone is an Effective and Well Tolerated Systemic Antiandrogen Therapy for Hirsute Women*
research A case series of 20 women with hidradenitis suppurativa treated with spironolactone
research Innovative use of spironolactone as an antiandrogen in the treatment of female pattern hair loss.
research Influence of spironolactone treatment on endothelial function in non-obese women with polycystic ovary syndrome
research Antiandrogen therapy with spironolactone for the treatment of hidradenitis suppurativa
research A comparison between spironolactone and spironolactone plus finasteride in the treatment of hirsutism
research Spironolactone: An Anti-androgenic and Anti-hypertensive Drug That May Provide Protection Against the Novel Coronavirus (SARS-CoV-2) Induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19
research Becker's Nevus with Ipsilateral Breast Hypoplasia: Improvement with Spironolactone
research Demographics of women with female pattern hair loss and the effectiveness of spironolactone therapy
research Successful treatment of female-pattern hair loss with spironolactone in a 9-year-old girl
research Cross-species sensitivity to a novel androgen receptor agonist of potential environmental concern, spironolactone
research Spironolactone for the Treatment of Acne: A 4-Year Retrospective Study
research Treatment of female pattern hair loss with a combination of spironolactone and minoxidil
research Beneficial effect of spironolactone on androgenic alopecia
research Spironolactone and XPB: An Old Drug with a New Molecular Target
research Spironolactone for treatment of female pattern hair loss
research Association of Spironolactone Use With Risk of Cancer
