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    Glossary Spironolactone

    medication that blocks hormones to treat hair loss and acne

    Spironolactone, also known by the brand name Aldactone, is a medication primarily used as a diuretic and antihypertensive. It works by blocking the action of aldosterone, a hormone that regulates salt and water balance in the body. In addition to its primary uses, it is also prescribed off-label for conditions like acne and hirsutism (excessive hair growth) due to its anti-androgenic properties, and it can be beneficial in treating certain types of hair loss, such as androgenetic alopecia.

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    1. Treatment of Hirsutism With Spironolactone JAMA · 1982 · 183 citations
    2. Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial Fertility and Sterility · 1994 · 165 citations
    3. The effects of two doses of spironolactone on serum androgens and anagen hair in hirsute women Fertility and sterility · 1985 · 142 citations
    4. A Novel Use of Spironolactone: Treatment of Hirsutism 1980 · 124 citations
    5. Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review American Journal of Clinical Dermatology · 2017 · 117 citations
    6. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne Cochrane library · 2009 · 112 citations
    7. Oral spironolactone therapy for female patients with acne, hirsutism or androgenic alopecia British Journal of Dermatology · 1985 · 101 citations
    8. Comparison of Spironolactone, Flutamide, and Finasteride Efficacy in the Treatment of Hirsutism: A Randomized, Double Blind, Placebo-Controlled Trial1 The Journal of Clinical Endocrinology and Metabolism · 2000 · 94 citations
    9. Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia International Journal of Nanomedicine · 2014 · 89 citations
    10. Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone International Journal of Dermatology · 2017 · 80 citations
    11. Side-Effects of Spironolactone Therapy in the Hirsute Woman 1988 · 80 citations
    12. Spironolactone is an Effective and Well Tolerated Systemic Antiandrogen Therapy for Hirsute Women* The Journal of Clinical Endocrinology & Metabolism · 1989 · 78 citations
    13. Comparison of finasteride versus spironolactone in the treatment of idiopathic hirsutism Fertility and Sterility · 1997 · 76 citations
    14. Improved Efficacy of Low-Dose Spironolactone and Metformin Combination Than Either Drug Alone in the Management of Women With Polycystic Ovary Syndrome (PCOS): A Six-Month, Open-Label Randomized Study The Journal of Clinical Endocrinology and Metabolism · 2013 · 75 citations
    15. Comparison of Sequential Cyproterone Acetate/Estrogen Versus Spironolactone/Oral Contraceptive in the Treatment of Hirsutism 1991 · 68 citations
    16. Use of cyproterone acetate, finasteride, and spironolactone to treat idiopathic hirsutism Fertility and Sterility · 2003 · 56 citations
    17. A case series of 20 women with hidradenitis suppurativa treated with spironolactone Australasian Journal of Dermatology · 2015 · 54 citations
    18. Innovative use of spironolactone as an antiandrogen in the treatment of female pattern hair loss. PubMed · 2010 · 53 citations
    19. A prospective randomized trial comparing finasteride to spironolactone in the treatment of hirsute women. The Journal of Clinical Endocrinology and Metabolism · 1995 · 52 citations
    20. Influence of spironolactone treatment on endothelial function in non-obese women with polycystic ovary syndrome European Journal of Endocrinology · 2011 · 50 citations
    21. The effect of spironolactone on genital skin 5α-reductase activity 1985 · 50 citations
    22. Antiandrogen therapy with spironolactone for the treatment of hidradenitis suppurativa Journal of The American Academy of Dermatology · 2018 · 48 citations
    23. A comparison between spironolactone and spironolactone plus finasteride in the treatment of hirsutism European journal of endocrinology · 2004 · 47 citations
    24. Spironolactone in combination drug therapy for unresponsive hirsutism Fertility and sterility · 1985 · 44 citations
    25. Androgens Affect the Activity of Human Sebocytes in Culture in a Manner Dependent on the Localization of the Sebaceous Glands and Their Effect Is Antagonized by Spironolactone Skin Pharmacology and Physiology · 1994 · 40 citations
    26. Spironolactone Therapy for Hirsutism in a Hyperandrogenic Woman Annals of internal medicine · 1978 · 39 citations
    27. Development and Optimisation of Spironolactone Nanoparticles for Enhanced Dissolution Rates and Stability Aaps Pharmscitech · 2016 · 38 citations
    28. Spironolactone: An Anti-androgenic and Anti-hypertensive Drug That May Provide Protection Against the Novel Coronavirus (SARS-CoV-2) Induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19 Frontiers in Medicine · 2020 · 36 citations
    29. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne 2003 · 32 citations
    30. THE EFFECT OF SPIRONOLACTONE ON HIRSUTISM AND FEMALE ANDROGEN METABOLISM Clinical endocrinology · 1985 · 32 citations