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    GlossaryTopical Spironolactone

    Topical spironolactone is a medication used in the treatment of androgenetic alopecia, particularly in women. It functions as an anti-androgen, inhibiting the effects of male hormones that can contribute to hair loss. Its relevance lies in its ability to reduce hair thinning and promote regrowth by blocking androgen receptors in hair follicles. Key distinguishing characteristics include its application as a topical solution or foam, which allows for localized treatment with potentially fewer systemic side effects compared to oral forms of spironolactone.

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      learn Spironolactone

      powerful topical and oral anti-androgen used mostly by women

      learn Fluridil

      a topical anti-androgen with less systemic involvement

      learn Clascoterone

      a novel topical treatment that inhibits DHT on androgen receptors

      learn RU58841

      a potent but unapproved and potentially problematic topical anti-androgen

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      community Any male on topical spironolactone?

      in Research/Science  7 upvotes 3 months ago
      Topical spironolactone is discussed for hair loss treatment, with mentions of DIY solutions and dermatologist compounding. Users inquire about regrowth and sourcing the treatment.

      community Topical spironolactone — how much do you apply?

      in Female  3 upvotes 9 months ago
      A user with androgenetic alopecia is using 8 ml of 1.4% topical spironolactone solution daily but is unsure if this amount is excessive, as 2 ml is more typical. They seek advice on the appropriate amount to apply.

      community Topical spironolactone — how many ml do you apply?

      in Female  7 upvotes 9 months ago
      The conversation discusses the use of topical spironolactone for hair loss, with the original poster applying 8 ml daily but learning that 2 ml is recommended. It also touches on hair transplants and the role of DHT sensitivity in hair loss, emphasizing individual differences in treatment outcomes.