Lack of Endocrine Systemic Side Effects After Topical Application of Spironolactone in Men

In a study from 1988 involving six healthy male volunteers, researchers found that topical application of a 5% spironolactone cream did not result in systemic absorption or endocrine side effects. Measurements of blood and urinary levels of spironolactone's major metabolite, as well as various hormone levels, showed no detectable changes over 72 hours post-application. This suggests that spironolactone, when used topically, acts locally on the skin without systemic endocrine side effects, contrasting with the known effects of oral administration. The study also noted a case of contact dermatitis from spironolactone cream, but without determining the rate of skin penetration.