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    Lack of Endocrine Systemic Side Effects After Topical Application of Spironolactone in Men

    François Rey, C. Valterio, L. Locatelli … J. P. Felber
    Studysummary This study found that topically administered spironolactone in healthy volunteers resulted in no detectable systemic absorption or changes in related hormone levels over 72 hours, indicating local effect only.
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    Research cited in this study 6

    1. Lack of Effect of a Spironolactone-Containing Cream on Hair Growth in Hirsute Women Dermatology · 2009
    2. The Effect of Spironolactone on Hirsutism and Female Androgen Metabolism Clinical endocrinology · 1985
    3. The Effect of Spironolactone on Genital Skin 5α-Reductase Activity Journal of steroid biochemistry/Journal of Steroid Biochemistry · 1985
    4. The Effects of Two Doses of Spironolactone on Serum Androgens and Anagen Hair in Hirsute Women Fertility and sterility · 1985
    5. Treatment of Hirsutism With Spironolactone JAMA · 1982
    6. A Novel Use of Spironolactone: Treatment of Hirsutism ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 1980