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Lack of Endocrine Systemic Side Effects After Topical Application of Spironolactone in Men

research Lack of endocrine systemic side effects after topical application of spironolactone in man

8 citations , April 1988 in “Journal of endocrinological investigation”

This study found that topically administered spironolactone in healthy volunteers resulted in no detectable systemic absorption or changes in related hormone levels over 72 hours, indicating local effect only.

research Adverse effects of finasteride in men treated for benign prostatic hyperplasia and androgenetic alopecia - a literature review

March 2025 in “Journal of Education Health and Sport”

This review reported that while finasteride is effective for treating androgenetic alopecia and benign prostatic hyperplasia, it may cause adverse effects such as sexual dysfunction and psychological symptoms, which require careful patient education and management to ensure treatment adherence and satisfaction.

research Estrogen deprivation effects of endocrine therapy in breast cancer patients: Incidence, management and outcome

7 citations , September 2023 in “Cancer Treatment Reviews”

This review highlights the possible impact of side effects from endocrine therapy on quality of life, emphasizing that these can lead to poor adherence and early treatment discontinuation in patients with hormone receptor positive early breast cancer, potentially worsening survival outcomes.

research Clinical and endocrine effects of finasteride, a 5α-reductase inhibitor, in women with idiopathic hirsutism

70 citations , August 1995 in “Fertility and Sterility”

In this study, women with idiopathic hirsutism who took finasteride for 9 months experienced a significant reduction in hirsutism scores compared to those receiving a placebo, with minimal side effects.

research Synthesis and Actions of 5α-Reduced Metabolites of Testosterone in the Nervous System

1 citations , December 2021 in “Androgens”

This review discusses the effects of neuroactive testosterone metabolites on CNS functions and suggests their potential as therapeutic options for neurological disorders, but reports no new clinical results.

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Community Join

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community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

192 upvotes 4 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

community Trying to understand finasteride side effects and post finasteride syndrome

70 upvotes 5 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community Does the PG-free version of RU58841 have lower absorption compared to the PG version?

6 upvotes 11 months ago

The conversation discusses the absorption and effectiveness of PG-free versus PG versions of RU58841, with some users believing PG improves efficacy while others see no difference. Concerns about RU58841's potential side effects on the endocrine system are also mentioned, with one user considering switching to pyrilutamide.

community Clavicular claims Dutasteride has less negative effects than Finasteride, is this true?

in Finasteride/Dutasteride 3 upvotes 5 months ago

Dutasteride is reported to have fewer side effects than Finasteride, with some users experiencing higher libido and fewer sexual side effects on Dutasteride. However, individual responses vary, and some users find Finasteride more tolerable.

community If RU58841 is such an effective anti androgen

in Research/Science 46 upvotes 2 years ago

RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

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Learn

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learn Overview

learn Estradiol

Can Estradiol cause side effects in people without a hormonal imbalance? Estradiol can cause side effects even in hormonally balanced individuals.

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Clinics

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13
Hair Loss Treatments
DECON (Diabetes & Endocrine Center of Nevada) SparksSparks, NV · US

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