The Efficacy and Safety of Oral and Topical Spironolactone in Androgenetic Alopecia Treatment: A Systematic Review

    March 2023 in “ Clinical, Cosmetic and Investigational Dermatology ”
    Chaofan Wang, Yimei Du, Lingbo Bi … Weixin Fan
    Studysummary This study concluded that both oral and topical spironolactone effectively treat androgenetic alopecia, with topical administration being safer and suitable for any gender, especially when combined with minoxidil.
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    Research cited in this study 17

    1. Dermoscopic Evaluation of the Efficacy of Combination of Topical Spironolactone 5% and Minoxidil 5% Solutions in the Treatment of Androgenetic Alopecia: A Cross-Sectional Comparative Study Journal of Cosmetic Dermatology · 2022
    2. Efficacy and Safety of 5% Minoxidil Alone, Minoxidil Plus Oral Spironolactone, and Minoxidil Plus Microneedling on Female Pattern Hair Loss: A Prospective, Single-Center, Parallel-Group, Evaluator-Blinded, Randomized Trial Frontiers in Medicine · 2022
    3. Spironolactone in Dermatology Dermatologic Therapy · 2022
    4. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    5. A Novel Topical Combination of Minoxidil and Spironolactone for Androgenetic Alopecia: Clinical, Histopathological, and Physicochemical Study Dermatologic Therapy · 2020
    6. Combination Oral Minoxidil and Spironolactone for the Treatment of Androgenetic Alopecia in Adolescent Girls Journal of The American Academy of Dermatology · 2020
    7. Spironolactone in Dermatology: Uses in Acne and Beyond Clinical and Experimental Dermatology · 2020
    8. Spironolactone for Treatment of Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2020
    9. Female Pattern Hair Loss: A Clinical, Pathophysiologic, and Therapeutic Review International Journal of Women's Dermatology · 2018
    10. Efficacy of Non-Surgical Treatments for Androgenetic Alopecia: A Systematic Review and Network Meta-Analysis Journal of The European Academy of Dermatology and Venereology · 2018
    11. Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone International Journal of Dermatology · 2017
    12. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    13. Demographics of Women with Female Pattern Hair Loss and the Effectiveness of Spironolactone Therapy Journal of The American Academy of Dermatology · 2015
    14. Female Pattern Hair Loss: An Overview Current problems in dermatology · 2015
    15. Hair Loss in Women: Medical and Cosmetic Approaches to Increase Scalp Hair Fullness British Journal of Dermatology · 2011
    16. Treatment of Female Pattern Hair Loss with a Combination of Spironolactone and Minoxidil Australasian Journal of Dermatology · 2007
    17. Treatment of Female Pattern Hair Loss With Oral Antiandrogens British Journal of Dermatology · 2005

    Related research 10

    1. Pediatric Androgenetic Alopecia: An Updated Review Journal der Deutschen Dermatologischen Gesellschaft · 2023
    2. A Survey of Patient Attitudes Towards Topical Minoxidil in the Treatment of Hair Loss PubMed · 2022
    3. Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil JAAD case reports · 2022
    4. Efficacy and Safety Profile of Oral Spironolactone Use for Androgenic Alopecia: A Systematic Review PubMed · 2021
    5. Efficacy of Systemic Minoxidil and Tofacitinib Combination in Treatment-Resistant Alopecia Universalis Journal of Cosmetic Dermatology · 2020
    6. Spironolactone for Treatment of Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2020
    7. The Use of Trichoscopy to Assess the Efficacy of Topical Minoxidil 2% Solution in Patients with Female Pattern Hair Loss Zagazig university medical journal · 2019
    8. Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone International Journal of Dermatology · 2017
    9. Treatment of Female Pattern Hair Loss with the Androgen Receptor Antagonist Flutamide Australasian Journal of Dermatology · 2011
    10. Treatment of Female Pattern Hair Loss with a Combination of Spironolactone and Minoxidil Australasian Journal of Dermatology · 2007