Efficacy of Non-Surgical Treatments for Androgenetic Alopecia: A Systematic Review and Network Meta-Analysis

    Anik Gupta, Rachel R. Mays, M. S. Dotzert … Vincent Piguet
    Studysummary This study found that low-level laser therapy was the most effective non-surgical treatment for androgenetic alopecia, although the overall quality of evidence supporting various therapies was generally low.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on orca.cardiff.ac.uk →
    Discuss this study in the Community →

    Research cited in this study 77

    1. Low-Level Laser Therapy for the Treatment of Androgenic Alopecia: A Review Lasers in Medical Science · 2017
    2. Randomized Trial of Electrodynamic Microneedle Combined with 5% Minoxidil Topical Solution for the Treatment of Chinese Male Androgenetic Alopecia Journal of Cosmetic and Laser Therapy · 2017
    3. Comparison of the Effects of 665 nm Low-Level Diode Laser Hat Versus a Combination of 665 nm and 808 nm Low-Level Diode Laser Scanner on Hair Growth in Androgenic Alopecia Journal of Cosmetic and Laser Therapy · 2017
    4. The Effect of Autologous Activated Platelet-Rich Plasma Injection on Female Pattern Hair Loss: A Randomized Placebo-Controlled Study Journal of Cosmetic Dermatology · 2017
    5. Low-Level Light and Minoxidil 5% Combination Versus Either Modality Alone in Management of Female Patterned Hair Loss: A Randomized Controlled Study Lasers in Surgery and Medicine · 2017
    6. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    7. Assessing Finasteride-Associated Sexual Dysfunction Using the FAERS Database Journal of The European Academy of Dermatology and Venereology · 2017
    8. Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems International Journal of Molecular Sciences · 2017
    9. An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% Versus Minoxidil 5% Solution in Male Androgenetic Alopecia Skin Pharmacology and Physiology · 2017
    10. Differences in Reproductive Toxicology Between Alopecia Drugs: An Analysis on Adverse Events Among Female and Male Cases Oncotarget · 2016
    11. Persistent Sexual Dysfunction with Finasteride 1 mg Taken for Hair Loss Pharmacotherapy · 2016
    12. A Mechanistic Model of Platelet-Rich Plasma Treatment for Androgenetic Alopecia Dermatologic Surgery · 2016
    13. Efficacy of Platelet-Rich Plasma in the Treatment of Androgenetic (Male-Patterned) Alopecia: A Pilot Randomized Controlled Trial Journal of Cosmetic and Laser Therapy · 2016
    14. Superiority of Dutasteride Over Finasteride in Hair Regrowth and Reversal of Miniaturization in Men With Androgenetic Alopecia: A Randomized Controlled Open-Label, Evaluator-Blinded Study Indian Journal of Dermatology, Venereology and Leprology · 2016
    15. Meta-Analysis of Efficacy of Platelet-Rich Plasma Therapy for Androgenetic Alopecia Journal of Dermatological Treatment · 2016
    16. The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial Stem Cells Translational Medicine · 2015
    17. Combined Treatment with Oral Finasteride and Topical Minoxidil in Male Androgenetic Alopecia: A Randomized and Comparative Study in Chinese Patients Dermatologic Therapy · 2015
    18. A Single-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Investigate the Efficacy and Safety of Minoxidil Topical Foam in Frontotemporal and Vertex Androgenetic Alopecia in Men Skin Pharmacology and Physiology · 2015
    19. The Growth of Human Scalp Hair in Females Using Visible Red Light Laser and LED Sources Lasers in Surgery and Medicine · 2014
    20. Exogenous IGF-1 Promotes Hair Growth by Stimulating Cell Proliferation and Downregulating TGF-β1 in C57BL/6 Mice In Vivo Growth Hormone & IGF Research · 2014
    21. Efficacy and Safety of a Low-Level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter, Randomized, Sham Device-Controlled, Double-Blind Study American Journal of Clinical Dermatology · 2014
    22. A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2014
    23. The Effect of Autologous Activated Platelet Rich Plasma Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation BioMed Research International · 2014
    24. The Growth of Human Scalp Hair Mediated by Visible Red Light Laser and LED Sources in Males Lasers in Surgery and Medicine · 2013
    25. Preparation and Evaluation of a Multimodal Minoxidil Microemulsion Versus Minoxidil Alone in the Treatment of Androgenic Alopecia of Mixed Etiology: A Pilot Study Drug Design Development and Therapy · 2013
    26. Comparative Effectiveness of Finasteride vs Serenoa Repens in Male Androgenetic Alopecia: A Two-Year Study International Journal of Immunopathology and Pharmacology · 2012
    27. Global Photographic Assessment of Men Aged 18 to 60 Years with Male Pattern Hair Loss Receiving Finasteride 1 mg or Placebo Journal of The American Academy of Dermatology · 2012
    28. Efficacy, Safety, and Tolerability of Dutasteride 0.5 mg Once Daily in Male Patients with Male Pattern Hair Loss: A Randomized, Double-Blind, Placebo-Controlled, Phase III Study Journal of The American Academy of Dermatology · 2010
    29. Comparing the Therapeutic Effects of Finasteride Gel and Tablet in Treatment of Androgenetic Alopecia Indian Journal of Dermatology, Venereology and Leprology · 2009
    30. HairMax LaserComb Laser Phototherapy Device in the Treatment of Male Androgenetic Alopecia Clinical Drug Investigation · 2009
    31. A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2007
    32. Comparison of the Efficacy and Safety of Topical Minoxidil and Topical Alfatradiol in the Treatment of Androgenetic Alopecia in Women Journal der Deutschen Dermatologischen Gesellschaft · 2007
    33. Dutasteride Improves Male Pattern Hair Loss in a Randomized Study in Identical Twins Journal of Cosmetic Dermatology · 2007
    34. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    35. Changes in Hair Weight in Men with Androgenetic Alopecia After Treatment with Finasteride (1 mg Daily): Three- and Four-Year Results Journal of The American Academy of Dermatology · 2006
    36. A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    37. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    38. Minoxidil vs Finasteride in the Treatment of Men With Androgenetic Alopecia Archives of Dermatology · 2003
    39. Treatment of Hyperandrogenic Alopecia in Women Fertility and Sterility · 2003
    40. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    41. Comparative Efficacy of Various Treatment Regimens for Androgenetic Alopecia in Men Journal of Dermatology · 2002
    42. Male Androgenetic Alopecia Clinical and Experimental Dermatology · 2002
    43. Changes in Hair Weight and Hair Count in Men with Androgenetic Alopecia After Treatment with Finasteride, 1 mg, Daily Journal of The American Academy of Dermatology · 2002
    44. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    45. Lack of Efficacy of Finasteride in Postmenopausal Women with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2000
    46. Finasteride Increases Anagen Hair in Men with Androgenetic Alopecia British Journal of Dermatology · 2000
    47. Measuring Reversal of Hair Miniaturization in Androgenetic Alopecia by Follicular Counts in Horizontal Sections of Serial Scalp Biopsies: Results of Finasteride 1mg Treatment of Men and Postmenopausal Women Journal of Investigative Dermatology Symposium Proceedings · 1999
    48. Improvement in Androgenetic Alopecia in 53-76-Year-Old Men Using Oral Finasteride International Journal of Dermatology · 1999
    49. Changes in Hair Weight and Hair Count in Men with Androgenetic Alopecia After Application of 5% and 2% Topical Minoxidil, Placebo, or No Treatment Journal of The American Academy of Dermatology · 1999
    50. Finasteride in the Treatment of Men with Frontal Male Pattern Hair Loss Journal of The American Academy of Dermatology · 1999
    51. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    52. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997
    53. Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect Journal of Investigative Dermatology · 1997
    54. Vascular Endothelial Growth Factor Is an Autocrine Growth Factor for Hair Dermal Papilla Cells Journal of Investigative Dermatology · 1996
    55. Androgenetic Alopecia in the Female Archives of Dermatology · 1994
    56. Use of Topical Minoxidil Therapy for Androgenetic Alopecia in Women International Journal of Dermatology · 1993
    57. Treatment of Female Androgenetic Alopecia with Minoxidil 2% International Journal of Dermatology · 1992
    58. Quantitative Estimation of Hair Growth: Androgenetic Alopecia in Women and the Effect of Minoxidil Journal of Investigative Dermatology · 1990
    59. Australian Trial of Topical Minoxidil and Placebo in Early Male Pattern Baldness Australasian Journal of Dermatology · 1990
    60. Quantitative Assessment of 2% Topical Minoxidil in the Treatment of Male Pattern Baldness Clinical and Experimental Dermatology · 1989
    61. Histologic Response to Topically Applied Minoxidil in Male-Pattern Alopecia Clinics in Dermatology · 1988
    62. Topical Minoxidil: Cardiac Effects in Bald Men British Journal of Clinical Pharmacology · 1988
    63. Treatment of Male Pattern Alopecia Using Topical Minoxidil in The Netherlands International Journal of Dermatology · 1988
    64. The German Double-Blind Placebo-Controlled Evaluation of Topical Minoxidil Solution in the Treatment of Early Male Pattern Baldness International Journal of Dermatology · 1988
    65. Topical Minoxidil in Androgenetic Alopecia: Scandinavian and Middle East Experience International Journal of Dermatology · 1988
    66. Comparable Efficacy of 2% Minoxidil Gel and Solution Formulations in the Treatment of Male Pattern Alopecia Journal of the American Academy of Dermatology · 1988
    67. Topical Minoxidil Therapy for Androgenetic Alopecia Archives of Dermatology · 1987
    68. Androgenetic Alopecia Treated With Topical Minoxidil Journal of The American Academy of Dermatology · 1987
    69. Topical Minoxidil in Early Androgenetic Alopecia Journal of The American Academy of Dermatology · 1987
    70. Androgenetic Alopecia: Treatment Results with Topical Minoxidil Journal of The American Academy of Dermatology · 1987
    71. Safety and Efficacy of Topical Minoxidil in the Management of Androgenetic Alopecia Journal of The American Academy of Dermatology · 1987
    72. Use of Topical Minoxidil in the Treatment of Male Pattern Baldness Journal of The American Academy of Dermatology · 1987
    73. Long-Term Efficacy of Topical Minoxidil in Male Pattern Baldness Journal of The American Academy of Dermatology · 1987
    74. Dose-Response Study of Topical Minoxidil in Male Pattern Alopecia Journal of The American Academy of Dermatology · 1987
    75. 2% Topical Minoxidil Solution in Male-Pattern Baldness: Preliminary European Results Dermatology · 1987
    76. Dose-Response Study of Topical Minoxidil in Male Pattern Baldness Journal of The American Academy of Dermatology · 1986
    77. Topical Minoxidil Therapy in Hereditary Androgenetic Alopecia Archives of Dermatology · 1985

    Related research 10

    1. What's New in Therapy for Male Androgenetic Alopecia? American Journal of Clinical Dermatology · 2022
    2. Comparison of Oral Minoxidil, Finasteride, and Dutasteride for Treating Androgenetic Alopecia Journal of Dermatological Treatment · 2022
    3. Combination Therapy with Oral Minoxidil and Dutasteride in the Treatment of Male Patterned Baldness: A Case Report Cosmoderma · 2022
    4. Pharmacological Therapeutics in Androgenetic Alopecia Journal of The Korean Medical Association · 2020
    5. Mesotherapy with Dutasteride and Minoxidil in the Treatment of Androgenetic Alopecia Journal of The American Academy of Dermatology · 2018
    6. A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2018
    7. Efficacy of Non-Surgical Treatments for Androgenetic Alopecia: A Systematic Review and Network Meta-Analysis Journal of The European Academy of Dermatology and Venereology · 2018
    8. Male Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2010
    9. Dutasteride Improves Hair Growth in Patients with Male Pattern Baldness More Effectively Than Finasteride Inpharma Weekly · 2007
    10. Effective Treatment of Female Androgenic Alopecia with Dutasteride PubMed · 2005