Dose-Response Study of Topical Minoxidil in Male Pattern Alopecia

March 1987 in “ Journal of The American Academy of Dermatology ”

Jerome L. Shupack, J.J. Kassimir, T Thirumoorthy, Michael D. Reed, L. Jondreau

topical minoxidil male pattern alopecia hair growth placebo prophylactic use Rogaine male pattern baldness

TLDR Minoxidil 1% and 2% best promote hair growth and may prevent hair loss.

This study investigated the effectiveness of different concentrations of topical minoxidil in promoting hair growth in men with male pattern baldness. Patients were treated with 0.01%, 0.1%, 1%, or 2% minoxidil or placebo for 6 months. The study found that 1% and 2% minoxidil solutions were the most effective in producing clinically perceptible hair growth, while 0.1% was the lowest efficacious concentration. The study also suggested that prophylactic use of minoxidil may be important in preventing hair loss.

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Research cited in this study

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research Topical Minoxidil in Early Male Pattern Baldness

138 citations, August 1985 in “Journal of The American Academy of Dermatology”

Minoxidil promotes hair growth in male pattern baldness.

research Topical Minoxidil Therapy in Hereditary Androgenetic Alopecia

55 citations, February 1985 in “Archives of Dermatology”

Using minoxidil on the scalp can help grow hair for people with hereditary baldness.

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community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

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in Research/Science 42 upvotes 1 week ago

Cyclosporine A is discussed as a powerful hair growth stimulant, potentially more effective than minoxidil, but concerns about safety and side effects, including cancer risk, limit its use. The conversation highlights the need for further research and experimentation with topical application, despite its risks.

community Taking Charge of Your Hair: The "Big 3 Stack" Explained for 2023

in Research/Science 129 upvotes 1 year ago

The "Big 3 Stack" for hair loss treatment, which includes Minoxidil for hair density improvement, Ketoconazole shampoo for enhancing hair volume and thickness, and Finasteride for blocking hair loss causing hormones. Microneedling can boost Minoxidil's effects.

community COMPLETE OVERVIEW of the Treatment of androgenetic alopecia in men

26 upvotes 10 years ago

Male androgenetic alopecia is commonly treated with topical minoxidil and oral finasteride, both requiring continuous use. Other options include hair restoration surgery, dutasteride, light therapy, and camouflaging agents.

community Hair Loss Drugs Ranked in Order of Efficacy

in Research/Science 67 upvotes 1 year ago

Dutasteride is likely the most effective treatment for male pattern baldness, followed by finasteride and minoxidil in various forms and dosages. Users discuss personal experiences, dosages, and potential side effects, with some considering combining treatments for better results.

community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

in Research/Science 14 upvotes 5 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.