Androgenetic Alopecia and Its Remedies: A Review

August 2014 in “ Journal of drug discovery and therapeutics ”

Rajesh Asija

androgenetic alopecia hair loss hair growth cycle anagen catagen telogen topical minoxidil oral finasteride Rogaine Propecia

TLDR Topical minoxidil and oral finasteride can help regrow hair in androgenetic alopecia.

The review discussed androgenetic alopecia, a common form of hair loss affecting both men and women, characterized by a progressive loss of hair in a specific pattern. It highlighted the psychological impact of hair loss on self-esteem and self-image. The paper explained the hair growth cycle, which includes the anagen (active), catagen (regressive), and telogen (resting) stages. The review focused on the diagnosis, pathophysiology, and medical treatments for androgenetic alopecia, specifically mentioning the use of topical minoxidil and oral finasteride as current treatment options to stimulate hair regrowth.

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Research cited in this study

13 / 13 results

research Psychological Effect, Pathophysiology, and Management of Androgenetic Alopecia in Men

112 citations, October 2005 in “Mayo Clinic Proceedings”

Minoxidil and finasteride can slow hair loss and stimulate regrowth, but won't restore all lost hair or reverse complete baldness.

research Evaluation and Treatment of Male and Female Pattern Hair Loss

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Early diagnosis and treatment, using finasteride, minoxidil, or hair transplantation, improves hair loss outcomes.

research Pathobiology of Androgenetic Alopecia

5 citations, November 2003 in “Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic”

The exact causes of baldness are not fully understood, limiting treatment options.

research Minoxidil vs Finasteride in the Treatment of Men With Androgenetic Alopecia

40 citations, September 2003 in “Archives of Dermatology”

Finasteride slightly better long-term, minoxidil faster initial results, but stopping minoxidil may cause hair loss.

research Androgenetic Alopecia: Pathogenesis and Potential for Therapy

174 citations, November 2002 in “Expert Reviews in Molecular Medicine”

Hair loss needs more research for better treatments.

research Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment

123 citations, February 2002 in “Journal of The American Academy of Dermatology”

Minoxidil can cause skin allergy; use alternative solvents or treatments if allergic.

research Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss

116 citations, September 2001 in “Journal of The American Academy of Dermatology”

Hair loss occurs due to fewer papillary cells, smaller follicles, and shorter growth phases.

research The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia

65 citations, October 1999 in “Journal of The American Academy of Dermatology”

Finasteride effectively reduces hair loss by decreasing androgen levels.

research Male Pattern Hair Loss: Current Understanding

59 citations, August 1998 in “International Journal of Dermatology”

Genetics and hormones cause hair loss; finasteride treats it safely.

research 5α-Reductase Inhibitors: A New Hope in Dermatology?

15 citations, March 1997 in “International Journal of Dermatology”

Finasteride shows promise for treating hair loss and excessive hair growth, but more research is needed to confirm its effectiveness and safety.

Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

research Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

81 citations, February 1997 in “Journal of Investigative Dermatology”

Minoxidil boosts hair growth by activating PGHS-1.

research Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia

309 citations, May 1993 in “Journal of The American Academy of Dermatology”

Horizontal scalp biopsy sections effectively diagnose and predict MPAA, with follicular density and inflammation impacting hair regrowth.

research Hair Follicle Embryogenesis in Humans: Characterization of Events In Vivo and In Vitro

14 citations, December 1991 in “PubMed”

The document explains how hair follicles develop in humans.

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Impairment of Autophagy May Be Associated with Follicular Miniaturization in Androgenetic Alopecia by Inducing Premature Catagen

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research Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients

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research The Genetically Programmed Hair Growth Cycle And Alopecia: What Is There To Know?

3 citations, June 2006 in “Expert Review of Dermatology”

The document concludes that hair loss is complex, affects many people, has limited treatments, and requires more research on its causes and psychological impact.

research The Change of the Frontal Hairline According to the Treatment for Androgenetic Alopecia

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research Hair Loss Unrelated to Androgenetic Alopecia

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research Pathobiology of Androgenetic Alopecia

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research Apoptosis, Androgenetic Alopecia, and the Hair Cycle

January 2002 in “Hair transplant forum international”

Finasteride reduces hair follicle cell death in androgenetic alopecia.

Androgenetic Alopecia and Its Remedies: A Review

Research cited in this study

research Psychological Effect, Pathophysiology, and Management of Androgenetic Alopecia in Men

research Evaluation and Treatment of Male and Female Pattern Hair Loss

research Pathobiology of Androgenetic Alopecia

research Minoxidil vs Finasteride in the Treatment of Men With Androgenetic Alopecia

research Androgenetic Alopecia: Pathogenesis and Potential for Therapy

research Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment

research Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss

research The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia

research Male Pattern Hair Loss: Current Understanding

research 5α-Reductase Inhibitors: A New Hope in Dermatology?

research Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

research Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia

research Hair Follicle Embryogenesis in Humans: Characterization of Events In Vivo and In Vitro

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research Managing Patterned Hair Loss – A Hair Raising Task!

research Caffeine and Its Role in Regulating Androgenetic Alopecia

research Impairment of Autophagy May Be Associated with Follicular Miniaturization in Androgenetic Alopecia by Inducing Premature Catagen

research Androgenetic Alopecia: Clinical Treatment

research Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients

research Common Hair Problems: Dandruff and Androgenetic Alopecia

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research Apoptosis, Androgenetic Alopecia, and the Hair Cycle