Androgenetic Alopecia and Its Remedies: A Review

August 2014 in “ Journal of drug discovery and therapeutics ”

Rajesh Asija

androgenetic alopecia hair loss hair growth cycle anagen catagen telogen topical minoxidil oral finasteride Rogaine Propecia

From the encyclopedia

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Finasteride →

Frontline, gold standard treatment for combatting androgenic alopecia

Studysummary This review discusses the diagnosis, pathophysiology, growth cycle, and medical treatment of androgenetic alopecia and offers no new clinical results. Our plain-language summary of this paper — not a Tressless recommendation.

The review discussed androgenetic alopecia, a common form of hair loss affecting both men and women, characterized by a progressive loss of hair in a specific pattern. It highlighted the psychological impact of hair loss on self-esteem and self-image. The paper explained the hair growth cycle, which includes the anagen (active), catagen (regressive), and telogen (resting) stages. The review focused on the diagnosis, pathophysiology, and medical treatments for androgenetic alopecia, specifically mentioning the use of topical minoxidil and oral finasteride as current treatment options to stimulate hair regrowth.

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research Psychological Effect, Pathophysiology, and Management of Androgenetic Alopecia in Men

112 citations , October 2005 in “Mayo Clinic Proceedings”

This article reviews the clinical, psychological, and management aspects of androgenetic alopecia in men, stating that it can be effectively managed by generalist clinicians with pharmacotherapy and surgical advancements.

research Evaluation and Treatment of Male and Female Pattern Hair Loss

203 citations , December 2004 in “Journal of The American Academy of Dermatology”

This article reviews the historical developments in understanding and treating male pattern hair loss, emphasizing the role of dihydrotestosterone and 5α-reductase inhibitors, but reports no new clinical findings.

research Pathobiology of Androgenetic Alopecia

5 citations , November 2003 in “Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic”

This review explores the key factors influencing hair growth implicated in androgenetic alopecia and reports no new clinical findings.

research Minoxidil vs Finasteride in the Treatment of Men With Androgenetic Alopecia

40 citations , September 2003 in “Archives of Dermatology”

This webpage provides access options for JAMA Dermatology but does not contain research findings or results.

research Androgenetic Alopecia: Pathogenesis and Potential for Therapy

174 citations , November 2002 in “Expert Reviews in Molecular Medicine”

This review discusses the genetic factors contributing to androgenetic alopecia and highlights the potential for developing more effective therapies based on recent discoveries, but reports no new clinical results.

research Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment

123 citations , February 2002 in “Journal of The American Academy of Dermatology”

Minoxidil can cause skin allergy; use alternative solvents or treatments if allergic.

research Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss

116 citations , September 2001 in “Journal of The American Academy of Dermatology”

This study suggests that miniaturization in pattern hair loss may occur abruptly and can be reversed with treatment, as supported by histologic evidence in finasteride-responsive patients.

research The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia

65 citations , October 1999 in “Journal of The American Academy of Dermatology”

In this study, finasteride doses as low as 0.2 mg per day significantly reduced both scalp skin and serum DHT levels in men with androgenetic alopecia.

research Male Pattern Hair Loss: Current Understanding

59 citations , August 1998 in “International Journal of Dermatology”

Genetics and hormones cause hair loss; finasteride treats it safely.

research 5α-Reductase Inhibitors: A New Hope in Dermatology?

15 citations , March 1997 in “International Journal of Dermatology”

This article discusses the potential use of 5α-reductase inhibitors in dermatology and reports no new clinical results; the authors suggest further exploration of their dermatological applications.

Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

research Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

81 citations , February 1997 in “Journal of Investigative Dermatology”

This study suggests that minoxidil activates PGHS-1, which may explain its hair growth-stimulating effects and could aid in designing more potent hair growth-promoting drugs.

research Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia

309 citations , May 1993 in “Journal of The American Academy of Dermatology”

This study concluded that horizontal sections of scalp biopsy specimens provide more diagnostic information for male pattern androgenetic alopecia than vertical sections and can predict hair regrowth potential following topical minoxidil therapy.

research Hair Follicle Embryogenesis in Humans: Characterization of Events In Vivo and In Vitro

14 citations , December 1991 in “PubMed”

The document explains how hair follicles develop in humans.