Pathobiology of Androgenetic Alopecia

November 2003 in “ Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic ”

Michala Fiuraskova, Renata Kučerová Ph.D, Zdenek Kolar

androgenetic alopecia androgens 5α-reductase β-catenin p63 androgenic alopecia 5-alpha-reductase

TLDR The exact causes of baldness are not fully understood, limiting treatment options.

The document reviewed the pathobiology of androgenetic alopecia, highlighting the cyclic stages of hair growth and key factors like androgens, 5α-reductase, β-catenin, and p63 that influence baldness. Despite identifying these factors, the cell biological and molecular mechanisms were still poorly understood, limiting treatment options.

View this study on biomed.papers.upol.cz →

Discuss this study in the Community →

Research cited in this study

17 / 17 results

research Molecular Mechanisms of Androgenetic Alopecia

229 citations, August 2002 in “Experimental Gerontology”

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

research An Investigation of Apoptosis in Androgenetic Alopecia

19 citations, June 2002 in “American Journal of Dermatopathology”

Apoptosis contributes to hair loss in androgenetic alopecia.

research Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle

45 citations, April 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

Different Myc family proteins are located in various parts of the hair follicle and may affect stem cell behavior.

research Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1

28 citations, September 2000 in “Journal of Medicinal Chemistry”

Benzo[c]quinolizin-3-ones are effective nonsteroidal inhibitors of human steroid 5α-reductase 1.

research Androgen Receptor Antagonists Structure-Activity Relationships

204 citations, February 2000 in “Current Medicinal Chemistry”

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

research Neuroimmunoregulation of Androgens in the Adrenal Gland and the Skin

48 citations, January 2000 in “Hormone Research in Paediatrics”

Cytokines and neuropeptides are key in controlling androgen levels, affecting skin and hair conditions.

research In Vitro Main Pathways of Steroid Action in Cultured Hair Follicle Cells: Vascular Approach

30 citations, December 1999 in “Journal of Investigative Dermatology Symposium Proceedings”

Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.

research Expression of mRNA for Androgen Receptor, 5α-Reductase, and 17β-Hydroxysteroid Dehydrogenase in Human Dermal Papilla Cells

63 citations, November 1999 in “British journal of dermatology/British journal of dermatology, Supplement”

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

Minoxidil Increases 17β-Hydroxysteroid Dehydrogenase and 5α-Reductase Activity in Cultured Human Dermal Papilla Cells from Balding Scalp

research Minoxidil Increases 17β-Hydroxysteroid Dehydrogenase and 5α-Reductase Activity in Cultured Human Dermal Papilla Cells from Balding Scalp

34 citations, February 1999 in “Journal of Dermatological Science”

Minoxidil boosts enzymes that help hair growth.

research Androgen-Dependent Beard Dermal Papilla Cells Secrete Autocrine Growth Factors in Response to Testosterone Unlike Scalp Cells

51 citations, November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Beard cells, unlike scalp cells, produce growth factors in response to testosterone, which may explain differences in hair growth.

research Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne

186 citations, July 1998 in “Journal of Cutaneous Medicine and Surgery”

Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.

research Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp

227 citations, January 1998 in “Journal of Endocrinology”

Cells from balding scalps have more androgen receptors than cells from non-balding scalps.

Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations, September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research The Regulatory Biology of the Human Pilosebaceous Unit

17 citations, June 1997 in “Baillière's clinical obstetrics and gynaecology”

Scientists now better understand how human hair growth is controlled, including the roles of specific genes and proteins.

Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

19 citations, January 1997 in “Endocrinology”

Testosterone can slow hair growth in adult monkeys, but a blocker called RU 58841 can counteract this and potentially help hair regrow.

research A Comparison of the Culture and Growth of Dermal Papilla Cells from Hair Follicles from Non-Balding and Balding (Androgenetic Alopecia) Scalp

30 citations, March 1996 in “British Journal of Dermatology”

research Apoptosis in Human Skin Development: Morphogenesis, Periderm, and Stem Cells

253 citations, March 1994 in “Developmental dynamics”

Apoptosis is essential for human skin development and forming a functional epidermis.

Related Research

5 / 5 results

research Hair Loss (Alopecia or Baldness)

June 2018

Baldness is often hereditary and linked to male hormones, becoming noticeable when half the hair is lost.

research Treatments of Hereditary Hair Loss (Alopecia)

April 2018

Some treatments like minoxidil, finasteride, and surgery can help with hereditary hair loss.

Increased Scalp Skin and Serum 5a-Reductase Reduced Androgens in a Man Relevant to the Acquired Progressive Kinky Hair Disorder and Developing Androgenetic Alopecia

research Increased Scalp Skin and Serum 5a-Reductase Reduced Androgens in a Man Relevant to the Acquired Progressive Kinky Hair Disorder and Developing Androgenetic Alopecia

11 citations, September 1997 in “Archives of Dermatology”

Reduced androgens linked to kinky hair disorder and hair loss; 5a-reductase inhibitors may help.

research Clinical Updates in Hair

19 citations, January 1997 in “Dermatologic Clinics”

Most treatments for hair loss in 1997 were not effective for most people, and maintaining hair growth was difficult.

research Topical Minoxidil in Extensive Alopecia Areata, Including 3-Year Follow-Up

34 citations, January 1987 in “Dermatology”

Topical minoxidil effectively and safely treats extensive alopecia areata but doesn't change its course.