TLDR Scientists now better understand how human hair growth is controlled, including the roles of specific genes and proteins.
The document from 1997 discussed advancements in understanding the regulation of the human pilosebaceous unit, focusing on the roles of homeotic genes, transcription factors, growth factors, and adhesion molecules in hair growth. Key growth factors identified included epidermal growth factor and transforming growth factor-α, which trigger anagen and categen phases, insulin-like growth factor-I, which sustains anagen growth, and transforming growth factor-β, which inhibits it. Additionally, interleukin-1-α and tumor necrosis factor-α were found to induce matrix cell death. The study also began to elucidate the role of steroid hormones in modulating these growth factor effects, contributing to an integrated model of pilosebaceous regulation.
94 citations,
February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology” EGF makes hair follicles grow longer but stops hair production.
11 citations,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” 150 citations,
May 1993 in “The journal of cell biology/The Journal of cell biology” Mouse Notch is important for determining cell roles in hair follicles.
309 citations,
May 1993 in “Journal of The American Academy of Dermatology” Horizontal scalp biopsy sections effectively diagnose and predict MPAA, with follicular density and inflammation impacting hair regrowth.
578 citations,
April 1993 in “Cell” TGFα gene mutation in mice causes abnormal skin, wavy hair, curly whiskers, and sometimes eye inflammation.
39 citations,
April 1992 in “Development” Both cell and non-cell parts are important for rat whisker follicle regrowth.
124 citations,
April 1992 in “Journal of Endocrinology/Journal of endocrinology” Beard hair follicles have more androgen receptors than non-balding scalp hair follicles.
45 citations,
December 1991 in “Annals of the New York Academy of Sciences” ECM molecules are crucial for hair growth and development.
67 citations,
July 1985 in “British journal of dermatology/British journal of dermatology, Supplement” Men's thigh hair grows longer and has a longer growth cycle than women's, but arm hair growth is similar between genders.
175 citations,
April 1982 in “Journal of The American Academy of Dermatology” Isotretinoin is highly effective in treating severe acne, rosacea, and gram-negative folliculitis.
159 citations,
July 2006 in “Endocrine Reviews” Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.
Researchers found a genetic link for hereditary hair loss but need more analysis to identify the exact gene.
4 citations,
January 2013 in “Advances in Experimental Medicine and Biology” Certain transcription factors are key in controlling skin stem cell behavior and could impact future treatments for skin repair and hair loss.
130 citations,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).
97 citations,
March 2009 in “Dermato-endocrinology” Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.
