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GlossaryHomeobox Genes (Homeotic Genes)

regulatory genes controlling body plan and organ development

Homeobox genes, often referred to as Hox genes, are a group of regulatory genes that play a crucial role in determining the body plan and the formation of tissues and organs during early embryonic development. They contain a specific DNA sequence called the homeobox, which encodes a protein domain (the homeodomain) that can bind to DNA and regulate the expression of other genes. This precise regulation ensures that body structures form in the correct locations.

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research The Regulatory Biology of the Human Pilosebaceous Unit

17 citations, June 1997 in “Baillière's clinical obstetrics and gynaecology”

Scientists now better understand how human hair growth is controlled, including the roles of specific genes and proteins.

research Expression Analysis of KAP9.2 and Hoxc13 Genes During Different Cashmere Growth Stages by qRT-PCR Method

9 citations, June 2014 in “Molecular biology reports”

KAP9.2 and Hoxc13 genes are important for cashmere growth and vary in activity during different stages.

research The Hair Follicle as an Estrogen Target and Source

159 citations, July 2006 in “Endocrine Reviews”

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

research Region-Specific Reversal of Epidermal Planar Polarity in the Rosette Fancy Mouse

2 citations, August 2023 in “Development”

Hair follicles in the back of the rosette fancy mouse have reversed orientations due to a gene mutation.

research Hox in the Niche Controls Hair Heterogeneity

4 citations, October 2018 in “Cell Stem Cell”

Hox genes control hair growth patterns in mammals by regulating stem cell activity in the skin.

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