Clinical and Molecular Genetic Studies in Hereditary Hair Loss

August 2021

M.A.M. van Steensel

Hypotrichosis of Marie Unna autosomal dominant hair-loss disorder D8S258 D8S298 hr gene congenital atrichia positional cloning

TLDR Researchers found a genetic link for hereditary hair loss but need more analysis to identify the exact gene.

Researchers investigated the genetic basis of Hypotrichosis of Marie Unna (MU), an autosomal dominant hair-loss disorder, in a large Dutch family and a British kindred. They identified a linkage with marker D8S258 and localized the MU gene to a 2.4-cM interval between markers D8S258 and D8S298. Despite the proximity of the hr gene, known for causing congenital atrichia, no mutations were found in the hr gene in affected individuals. Further analysis and positional cloning of the MU locus are ongoing.

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