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Glossary Catagen Phase

hair growth stops and follicles shrink, lasting about 2-3 weeks

The Catagen Phase, also known as the Transitional Phase, is a short period in the hair growth cycle that lasts about 2-3 weeks. During this phase, hair growth stops, and the hair follicle shrinks and detaches from the dermal papilla, effectively transitioning the hair from the growth phase (Anagen) to the resting phase (Telogen). This phase is crucial for the renewal of hair follicles and the overall hair growth process.

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Research

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research Thrombospondin-1 Plays a Critical Role in the Induction of Hair Follicle Involution and Vascular Regression During the Catagen Phase

52 citations , January 2003 in “Journal of Investigative Dermatology”

This study found that thrombospondin-1 plays a critical role in hair follicle cycle regulation, with deficiency prolonging follicle growth and overexpression delaying it through antiangiogenic effects.

research Lipid peroxides induce early onset of catagen phase in murine hair cycles

49 citations , January 1998 in “International Journal of Molecular Medicine”

In this study, lipid peroxides were found to induce apoptosis in hair follicle cells and advance the catagen phase in mice, suggesting a potential mechanism for alopecia development.

research Expression of Cyclooxygenase Isozymes During Morphogenesis and Cycling of Pelage Hair Follicles in Mouse Skin: Precocious Onset of the First Catagen Phase and Alopecia upon Cyclooxygenase-2 Overexpression

41 citations , September 2003 in “Journal of Investigative Dermatology”

This study suggests that the COX-2 enzyme plays a role in hair follicle biology, as transgenic overexpression in mice induced hair follicle cycling disturbances and alopecia, which was mitigated by COX-2 inhibition.

research Identification of microRNAs in Wool Follicles during Anagen, Catagen, and Telogen Phases in Tibetan Sheep

37 citations , October 2013 in “PLoS ONE”

This study provides new insights into the identification and expression patterns of miRNAs in wool follicles, which could improve understanding of wool follicle development in sheep.

research Ginsenoside Re prevents 3-methyladenine-induced catagen phase acceleration by regulating Wnt/β-catenin signaling in human dermal papilla cells

5 citations , November 2022 in “Journal of Ginseng Research/Journal of ginseng research”

This study investigated the role of autophagy in human dermal papilla cells and found that inhibiting autophagy accelerates the catagen phase by reducing Wnt/β-catenin signaling. Furthermore, adding ginsenoside Re appears to restore autophagy, suggesting potential benefits for mitigating hair loss linked to autophagy inhibition.

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Community Join

5 / 61 results

community Who else is looking forward to full phase 2 results of PP405?

in Chat 59 upvotes 7 months ago

PP405 is a potential hair loss treatment showing promise, especially for men with severe balding. Some are hopeful it will be a game-changer for those who cannot tolerate finasteride or minoxidil, despite skepticism about the outcomes.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

211 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community Tretinoin for some men(not all) can cause non-telogen effluvium hair loss

in Research/Science 5 upvotes 1 year ago

Tretinoin can cause non-telogen hair loss in some men by inducing catagen-like changes in hair follicles and through retinoid toxicity, especially when used with minoxidil. Some users report hair loss even when using retinoids on the face, while others experience benefits when combined with treatments like finasteride and minoxidil.

community HMI-115 update: Chime Biologics and Hope Medicine Enter Manufacturing Agreement to Speed up the Launch of First-in-class Antibody Drug HMI-115 Targeting Endometriosis and Androgenic Alopecia

110 upvotes 2 years ago

Chime Biologics and Hope Medicine are speeding up the launch of a first-in-class antibody drug, HMI-115, for endometriosis and androgenic alopecia. The treatment involves a series of subcutaneous injections, has shown promising results in phase 1, and continues to promote hair regrowth even after the treatment is stopped.

community PP405 mechanism question - looking for discussion

7 upvotes 5 months ago

PP405 may promote short-term hair growth by pushing follicles into the growth phase, but concerns exist about long-term effects due to lack of rest phases. Users discuss various treatments like finasteride, minoxidil, spironolactone, alfatradiol, and investigational drugs like KX-826 and GT20029 for hair maintenance and regrowth.

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Learn

5 / 801 results

learn Dexpanthenol

precursor of vitamin B5 with hair stimulating effects

learn Exosomes

Microscopic delivery system that sends growth-promoting signals to hair follicles

learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

learn Vascular Endothelial Growth Factor

learn sh-Polypeptide-7

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