Transcriptional Control of Epidermal Stem Cells

    January 2013 in “ Advances in Experimental Medicine and Biology ”
    Briana Lee, Xing Dai
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    TLDR Certain transcription factors are key in controlling skin stem cell behavior and could impact future treatments for skin repair and hair loss.
    The document from 2013 reviews the transcriptional regulation of epidermal stem cells, highlighting the roles of specific transcription factors and chromatin regulators in the development, self-renewal, proliferation, and differentiation of these cells. It emphasizes the importance of transcription factors such as p63, TCF3, TCF4, RBP-J, Hes1, AP-2α, AP-2γ, Srf, and Ovol in maintaining the balance between stem cell proliferation and differentiation. The document also discusses the identification of adult skin stem cells, their multipotency, and their contribution to skin homeostasis and repair. It anticipates future research to further elucidate the roles of additional transcription factors, their interactions with chromatin factors, non-coding RNAs, and the regulation of the epigenomic landscape of stem/progenitor cells, which may have implications for regenerative medicine and alopecia therapies. The document acknowledges funding sources and apologizes for any omissions of work due to space constraints.
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