Epidermal Stem Cells Are Defined by Global Histone Modifications Altered by Myc-Induced Differentiation

    August 2007 in “ PLoS ONE ”
    Michaela Frye, Amanda G. Fisher, Fiona M. Watt
    Studysummary This study found that Myc activation in epidermal stem cells leads to chromatin modifications that promote stem cell exit and differentiation, which can be influenced by HDAC inhibitors like trichostatin A.
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    Research cited in this study 6

    1. Heterogeneous Stem Cells in Skin Homeostasis and Wound Repair The Indonesian Biomedical Journal · 2015
    2. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    3. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003
    4. Evidence That Myc Activation Depletes the Epidermal Stem Cell Compartment by Modulating Adhesive Interactions with the Local Microenvironment Development · 2003
    5. Deregulated Expression of c-Myc Depletes Epidermal Stem Cells Nature Genetics · 2001
    6. C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny Current Biology · 2001