Evidence That Myc Activation Depletes the Epidermal Stem Cell Compartment by Modulating Adhesive Interactions with the Local Microenvironment
May 2003
in “
Development
”
Myc activation epidermal stem cell adhesive interactions gene expression cell adhesion extracellular matrix integrins collagens sebocytes interfollicular epidermis hair lineages hemidesmosomes keratinocyte skin stem cells skin adhesion skin matrix skin integrins skin collagens skin cells skin healing skin behavior
TLDR Myc activation reduces skin stem cells by affecting cell adhesion.
The study demonstrated that Myc activation in transgenic mice led to the depletion of the epidermal stem cell compartment by altering adhesive interactions with the local microenvironment. This was evidenced by changes in gene expression, particularly the downregulation of genes related to cell adhesion and the extracellular matrix, such as integrins and collagens. Myc activation promoted differentiation into sebocytes and interfollicular epidermis rather than hair lineages, impairing cell adhesion, spreading, and motility. These effects were linked to decreased formation of hemidesmosomes and reduced expression of extracellular matrix proteins, contributing to delayed wound healing and altered keratinocyte behavior. The findings highlighted Myc's role in modulating stem cell behavior, impacting skin biology and diseases related to stem cell dysfunction.