Evidence That Myc Activation Depletes the Epidermal Stem Cell Compartment by Modulating Adhesive Interactions with the Local Microenvironment

    May 2003 in “ Development ”
    Michaela Frye, Clare Gardner, Elizabeth R. Li … Fiona M. Watt
    Studysummary This study found that Myc activation in mouse epidermis impairs keratinocyte adhesion and motility by downregulating extracellular matrix and cytoskeleton proteins, affecting hair lineage differentiation.
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    Research cited in this study 8

    1. Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors Development · 2002
    2. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001
    3. Deregulated Expression of c-Myc Depletes Epidermal Stem Cells Nature Genetics · 2001
    4. C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny Current Biology · 2001
    5. Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2001
    6. A Novel Serine Protease Overexpressed in the Hair Follicles of Nude Mice Biochemical and Biophysical Research Communications · 1999
    7. Reversible Activation of c-Myc in Skin Molecular Cell · 1999
    8. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development The Journal of Cell Biology · 1998