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Research

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CircRNA-0100 Positively Regulates the Differentiation of Cashmere Goat SHF-SCs into Hair Follicle Lineage via Sequestering miR-153-3p to Heighten the KLF5 Expression

research CircRNA-0100 positively regulates the differentiation of cashmere goat SHF-SCs into hair follicle lineage via sequestering miR-153-3p to heighten the KLF5 expression

9 citations , February 2022 in “Archives animal breeding/Archiv für Tierzucht”

This study found that circRNA-0100 promotes differentiation of secondary hair follicle stem cells into hair lineage in cashmere goats by sequestering miR-153-3p, which enhances KLF5 expression.

research Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics

1 citations , July 2023 in “Communications biology”

In this study, researchers found that deleting Med1, a key epigenetic regulator in dental epithelia, led to hair growth on mouse incisors by altering enhancer landscapes and causing a switch from dental to hair lineage transcription programs.

research Mediator 1 ablation induces enamel-to-hair lineage conversion through enhancer dynamics

September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that the deletion of Med1 in dental epithelia causes a shift from dental to hair tissue development, suggesting the importance of Med1 in maintaining tissue-specific lineage.

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

499 citations , September 2011 in “Cell”

This study found that intradermal adipocyte lineage cells in mice are necessary and sufficient to activate follicular stem cells, highlighting their role in regulating skin stem cell activity.

research Hair follicle dermal cells differentiate into adipogenic and osteogenic lineages

268 citations , December 2003 in “Experimental Dermatology”

This study demonstrated that clonal dermal papilla and dermal sheath cell lines from hair follicles can differentiate into lipid and bone cells, suggesting their potential as a stem cell source for tissue engineering.

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Community Join

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community Does My Grandfather Being Bald Mean I'm F***ed?

4 upvotes 9 years ago

Hair loss is influenced by multiple genetic factors, not just maternal lineage. Treatments like finasteride, minoxidil, and nizoral are suggested if male pattern baldness progresses.

community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

140 upvotes 11 months ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

373 upvotes 6 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

community New Hair Loss Cure: AMP-303 Is Back. It’s what PP405 should have been.

7 upvotes 5 months ago

AMP-303 and AMP-601 are new hair loss treatments targeting dermal papilla cells, with AMP-303 showing early efficacy in transitioning vellus hairs to terminal hairs after one injection. Further clinical trials are planned, and these treatments are seen as promising due to their biologic approach and less frequent application compared to daily treatments.

community Update on Amplifica (new drugs) and Engraft (new hair transplant technology)

65 upvotes 2 months ago

Amplifica is developing new molecules for hair growth, with clinical trials expected soon, while Engraft Technologies is improving FUE robotic technology to make hair transplants faster and cheaper. Users express interest in the timeline for AMP-303 and concerns about high costs and effectiveness of current treatments.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Stem Cell Factor

learn Hair Fibers

cosmetic product that temporarily makes hair appear thicker

Do hair fibers really make thinning hair look fuller, or is it just an illusion? Hair fibers create an optical illusion of fullness but do not actually thicken hair.
How do you apply hair fibers correctly so they stay in place all day? Apply hair fibers to clean, dry hair and use a setting spray for better hold.
Can hair fibers be used along with medical treatments like minoxidil or finasteride? Yes, hair fibers can be used with minoxidil or finasteride without any chemical interaction.
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learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Hair Transplant

Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.

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Clinics

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