Genetically Induced Cell Death in Bulge Stem Cells Reveals Their Redundancy for Hair and Epidermal Regeneration

    December 2014 in “ Stem Cells ”
    Iwona M. Driskell, Feride Oeztuerk-Winder, Peter Humphreys, Michaela Frye
    Studysummary This study found that quiescent bulge stem cells, when prevented from contributing to hair follicle and epidermal regeneration, did not affect hair follicle growth or wound healing in the short term.
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    Research cited in this study 20

    1. Macroenvironmental Regulation of Hair Cycling and Collective Regenerative Behavior Cold Spring Harbor Perspectives in Medicine · 2014
    2. Stem Cell Dynamics in the Hair Follicle Niche Seminars in Cell & Developmental Biology · 2013
    3. Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate Nature · 2013
    4. Age-Associated Inflammation Inhibits Epidermal Stem Cell Function Genes & development · 2012
    5. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    6. Identification of the Cell Lineage at the Origin of Basal Cell Carcinoma Nature Cell Biology · 2010
    7. Coexistence of Quiescent and Active Adult Stem Cells in Mammals Science · 2010
    8. Epidermal Stem Cell Diversity and Quiescence EMBO molecular medicine · 2009
    9. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    10. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    11. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    12. Epidermal Stem Cells Are Defined by Global Histone Modifications Altered by Myc-Induced Differentiation PLoS ONE · 2007
    13. The Cell-Surface Marker MTS24 Identifies a Novel Population of Follicular Keratinocytes With Characteristics of Progenitor Cells Development · 2006
    14. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    15. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003
    16. Evidence That Myc Activation Depletes the Epidermal Stem Cell Compartment by Modulating Adhesive Interactions with the Local Microenvironment Development · 2003
    17. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    18. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    19. Keratin 19 as a Biochemical Marker of Skin Stem Cells In Vivo and In Vitro: Localization and Variation with Age and Culture Stage Journal of Cell Science · 1996
    20. The Secret Life of the Hair Follicle Trends in genetics · 1992

    Related research 4

    1. Glutamate Transporter SLC1A3 Mediates Inter-Niche Stem Cell Activation During Skin Growth EMBO journal · 2018
    2. Lineage Analysis of Epidermal Stem Cells Cold Spring Harbor Perspectives in Medicine · 2014
    3. Epidermal Stem Cells: Practical Perspectives and Potential Uses British Journal of Dermatology · 2009
    4. Epidermal Stem Cells in the Skin Chinese bulletin of Life sciences · 2008