57 citations
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January 2013 in “International Journal of Medical Sciences” This study reports that Lef1 plays a crucial role in promoting bulge stem cell differentiation towards hair fate by activating β-catenin and downstream signaling pathways during hair follicle development.
54 citations
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December 2011 in “American Journal Of Pathology” This study found that immune-mediated destruction of bulge stem cells is a key factor in the alopecia observed in AE mice, suggesting it as a model for studying primary cicatricial alopecias, particularly lichen planopilaris.
37 citations
,
October 2009 in “Veterinary Dermatology” This study identified and isolated highly proliferative canine keratinocytes in vitro, finding that follicular keratinocytes showed distinct proliferative capacity and marker expression indicative of putative epithelial stem cells.
17 citations
,
July 2013 in “Amino Acids” This study found that elevated epidermal ODC activity in transgenic mice promotes skin tumor development by recruiting bulge stem cells, rather than through reactive oxygen species generation by polyamine catabolic oxidases.
13 citations
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December 2014 in “Stem Cells” This study found that quiescent bulge stem cells, when prevented from contributing to hair follicle and epidermal regeneration, did not affect hair follicle growth or wound healing in the short term.