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GlossaryHair Follicle Stem Cells (Bulge Stem Cells)

specialized cells in hair follicles that regenerate hair and skin

Hair Follicle Stem Cells (HFSCs) are specialized cells located in the bulge region of hair follicles. They play a crucial role in the growth and regeneration of hair by periodically activating to produce new hair shafts and contribute to the repair of skin injuries. These cells have the unique ability to self-renew and differentiate into various cell types, making them essential for maintaining healthy hair and skin.

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research Elevated Ornithine Decarboxylase Activity Promotes Skin Tumorigenesis by Stimulating the Recruitment of Bulge Stem Cells but Not via Toxic Polyamine Catabolic Metabolites

17 citations, July 2013 in “Amino Acids”

Increased ODC activity leads to skin tumors by recruiting stem cells, not by toxic byproducts.

research Genetically Induced Cell Death in Bulge Stem Cells Reveals Their Redundancy for Hair and Epidermal Regeneration

13 citations, December 2014 in “Stem Cells”

Hair and skin can regenerate without bulge stem cells due to other compensating cells.

research GDNF Promotes Hair Formation and Cutaneous Wound Healing by Targeting Bulge Stem Cells

7 citations, June 2020 in “npj regenerative medicine”

GDNF helps grow hair and heal skin wounds by acting on hair stem cells.

research TR3 Is Preferentially Expressed by Bulge Epithelial Stem Cells in Human Hair Follicles

7 citations, January 2016 in “Laboratory Investigation”

TR3 is mainly found in hair follicle stem cells and may be involved in hair loss.

research Identification of Bulge Stem Cells in Mouse and Human Hair Follicles

4 citations, January 2018 in “Microscopy research”

Scientists found markers called CD34 and CD200 that help identify stem cells in mouse and human hair follicles.

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community Redensyl Megathread !!!!

43 upvotes 5 years ago

Redensyl, which is a topical alternative to Minoxidil for hair loss. It may have advantages such as not making the hair greasy and lasting longer after discontinuing use than minoxidil. There are some positive reports from users, but also some negative ones, so it's unclear how effective this treatment will be in comparison to Minoxidil and other treatments like Finasteride or RU58841.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 828 upvotes 5 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community What are your thoughts on Redensyl? 85% success rate?!

in Treatment 6 upvotes 2 years ago

Hair loss discussion mentions Redensyl with 85% success rate and visible regrowth. Users skeptical, prefer Minoxidil, Finasteride, and RU58841.

community HairClone developing cell replacement treatments for Hair Loss

6 upvotes 6 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

community Best Microneedle Lengths To Stimulate Stem Cells

in Microneedling 18 upvotes 1 year ago

Microneedling with needle lengths of 1.5mm to 2.5mm to stimulate hair follicle stem cells for potential hair growth. Using needles longer than 2.5mm is not recommended due to risk of puncturing veins in the scalp. A dermastamp is suggested over a roller.

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