Identification of Bulge Stem Cells in Mouse and Human Hair Follicles

January 2018 in “ Microscopy research ”

Bélgica J. Molina, Elda Giansante, Héctor J. Finol

hair follicle bulge stem cells cytokeratin 15 CK15 CD34 CD200 immunohistochemical analysis immunofluorescence analysis progenitor cells partially differentiated cells stem cells

TLDR Scientists found markers called CD34 and CD200 that help identify stem cells in mouse and human hair follicles.

The study identified CD34 in mice and CD200 in humans as reliable biomarkers for bulge stem cells in hair follicles, using immunohistochemistry and immunofluorescence. CK15 was less specific. These markers could help isolate and study follicular stem cells, with potential applications in regenerative medicine. The study involved 7 mice and 7 human samples.

View this study on scirp.org →

Discuss this study in the Community →

Research cited in this study

14 / 14 results

research Differential Expression of Stem Cell Markers in Human Follicular Bulge and Interfollicular Epidermal Compartments

28 citations , March 2010 in “Histochemistry and Cell Biology”

Different markers are found in stem cells of the scalp's hair follicle bulge and the surrounding skin.

research Stem Cells and the Niche: A Dynamic Duo

333 citations , February 2010 in “Cell Stem Cell”

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

1039 citations , February 2009 in “Nature Reviews Molecular Cell Biology”

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Multipotent Nestin-Expressing Hair Follicle Stem Cells

37 citations , January 2009 in “The Journal of Dermatology”

Hair follicle stem cells can turn into various cell types and help repair nerves.

research The human keratins: biology and pathology

1398 citations , May 2008 in “Histochemistry and Cell Biology”

Keratins are crucial for cell stability, wound healing, and cancer diagnosis.

research Hair Follicle Stem Cells: Walking the Maze

165 citations , June 2007 in “European Journal of Cell Biology”

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

research Biology of the Hair Follicle: The Basics

224 citations , March 2006 in “Seminars in Cutaneous Medicine and Surgery”

The document concludes that understanding hair follicle biology can lead to better hair loss treatments.

research Bulge Cells of Human Hair Follicles: Segregation, Cultivation, and Properties

27 citations , January 2006 in “Colloids and Surfaces B: Biointerfaces”

Researchers found that bulge cells from human hair can grow quickly in culture and have properties of hair follicle stem cells, which could be useful for skin treatments.

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

550 citations , December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.

research Location and phenotype of human adult keratinocyte stem cells of the skin

233 citations , October 2004 in “Differentiation”

research Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge

387 citations , November 2003 in “Journal of Investigative Dermatology”

research Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermis

421 citations , September 2003 in “Development”

Stem cell behavior varies with stimuli, and lineage changes can happen without affecting stem cell division.

research Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34

561 citations , April 2003 in “Journal of Investigative Dermatology”

Related Community Posts Join

6 / 1000+ results

community Anti-oxidants that reverse hairloss?

in Research/Science 89 upvotes 4 years ago

Resveratrol and fisetin, found in red wine and strawberries, may promote hair growth by affecting hair follicle cells. Users discuss various treatments, including natural remedies like saw palmetto and topical applications, with mixed opinions on their effectiveness compared to pharmaceuticals like finasteride.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Am I missing something with pp405?

in Research/Science 32 upvotes 10 months ago

PP405 is discussed as a potential hair growth stimulant, possibly more effective than minoxidil, but not a cure for hair loss. There is skepticism about its ability to regrow "deadzones," and concerns about its impact on those with hair transplants.

community Clearing the air on how non-surgical treatments really work

18 upvotes 6 years ago

Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.

community It's always the Mice that gets to grow back hair.

in Research/Science 433 upvotes 2 weeks ago

Sodium dodecyl sulfate, oleic acid, and palmitoleic acid may promote hair growth, but their safety and effectiveness for humans are uncertain. Users consider trying these treatments cautiously, exploring alternatives like ostrich oil and microneedling.

Related Research

6 / 6 results

research Identification of Bulge Stem Cells in Mouse and Human Hair Follicles

4 citations , January 2018 in “Microscopy research”

Scientists found markers called CD34 and CD200 that help identify stem cells in mouse and human hair follicles.

Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

research Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

235 citations , January 2011 in “Journal of Clinical Investigation”

Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.