Bulge Cells of Human Hair Follicles: Segregation, Cultivation, and Properties

    January 2006 in “ Colloids and Surfaces B: Biointerfaces ”
    Yi Zhang, Mingming Xiang, Yun Wang, Jun Yan, Yijun Zeng, Jin Yü, Tian Yang
    Image of study
    TLDR Researchers found that bulge cells from human hair can grow quickly in culture and have properties of hair follicle stem cells, which could be useful for skin treatments.
    In the 2006 study by Zhang et al., researchers isolated and cultured bulge cells from human anagen hair follicles to investigate their properties as hair follicle stem cells (HFSCs). The cultured cells proliferated rapidly, with proliferation observed as early as day 2, peaking at day 6, and maintaining higher levels for several days. These cells exhibited undifferentiated features and expressed HFSC markers K19 and ß1-integrin, although these markers decreased over time in culture. The study confirmed that bulge cells are distinct from outer root sheath cells, with a higher colony-forming efficiency and the ability to generate the lower follicle and hair. The findings support the "Bulge Activation Hypothesis," suggesting that bulge-derived cells in vitro represent HFSCs in vivo, and highlight the potential of these cells for use in various dermatological applications. The number of hair follicles or bulge cells used was not specified in the summary.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 29 results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Best Microneedle Lengths To Stimulate Stem Cells

      in Microneedling  18 upvotes 1 year ago
      Microneedling with needle lengths of 1.5mm to 2.5mm to stimulate hair follicle stem cells for potential hair growth. Using needles longer than 2.5mm is not recommended due to risk of puncturing veins in the scalp. A dermastamp is suggested over a roller.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Redensyl Megathread !!!!

       46 upvotes 5 years ago
      Redensyl, which is a topical alternative to Minoxidil for hair loss. It may have advantages such as not making the hair greasy and lasting longer after discontinuing use than minoxidil. There are some positive reports from users, but also some negative ones, so it's unclear how effective this treatment will be in comparison to Minoxidil and other treatments like Finasteride or RU58841.

      community Clearing the air on how non-surgical treatments really work

       18 upvotes 5 years ago
      Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.

    Similar Research

    6 / 1000+ results