Search

for
Search:

Glossary Bulge Cells

specialized stem cells in hair follicles aiding growth and repair

Bulge cells are specialized stem cells located in the hair follicle's bulge area, which is a region near the base of the hair follicle. These cells play a crucial role in hair growth and regeneration, as they have the ability to differentiate into various cell types needed for the hair follicle's structure and function. For professionals, it's important to note that bulge cells are also involved in wound healing and can contribute to the regeneration of the epidermis.

Related Terms

Research

5 / 1000+ results

Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

research Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles

130 citations , January 1994 in “Differentiation”

In this study, researchers found that bulge cells in mouse hair follicles undergo transient proliferation during early anagen, indicating their role as follicular stem cells. However, another factor beyond dermal papilla proximity may be required to initiate a new anagen phase.

research Canine Follicle Stem Cell Candidates Reside in the Bulge and Share Characteristic Features with Human Bulge Cells

36 citations , April 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that canine bulge-derived keratinocytes are highly proliferative and can reconstitute pilosebaceous structures, indicating their potential utility in studying human stem cell biology and hair disorders.

research Differential expression of stem cell markers in human follicular bulge and interfollicular epidermal compartments

28 citations , March 2010 in “Histochemistry and Cell Biology”

This study identified specific markers that can distinguish between stem cells in different regions of human scalp hair follicles, offering potential strategies for cell sorting and purification based on these markers.

research Bulge cells of human hair follicles: segregation, cultivation and properties

27 citations , January 2006 in “Colloids and Surfaces B: Biointerfaces”

This study found that in vitro, cultured bulge cells from human hair follicles possess properties of primitive cells, supporting the hypothesis that hair follicle stem cells reside in the bulge area.

research The Hair Follicle Bulge: A Niche for Adult Stem Cells

19 citations , July 2011 in “Microscopy and Microanalysis”

This article reviews the role of adult stem cells in tissue homeostasis and wound repair, focusing on their regulation within the murine hair follicle's specialized niche, but it presents no new findings.

View more "bulge cells" in research →

Community Join

5 / 58 results

community UVA researchers discovered stem cells that plays a crucial role in hair growth - We are closer than ever to the cure!

281 upvotes 1 year ago

Researchers at the University of Virginia discovered a new group of stem cells in hair follicles that could potentially restore hair growth. The findings suggest that activating these stem cells might offer a new way to combat hair loss, though practical treatments are still years away.

community Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches

4 upvotes 11 years ago

Hair follicle regeneration through stem cell rearrangement is discussed, focusing on bioengineered cellular structures rather than traditional hair transplants. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Best Microneedle Lengths To Stimulate Stem Cells

18 upvotes 2 years ago

Microneedling with needle lengths of 1.5mm to 2.5mm to stimulate hair follicle stem cells for potential hair growth. Using needles longer than 2.5mm is not recommended due to risk of puncturing veins in the scalp. A dermastamp is suggested over a roller.

community Microneedling must reach the stem cells in the upper hair shaft

82 upvotes 4 years ago

Microneedling should target depths of 0.5mm to 1.5mm for hair loss, with weekly sessions at 1mm recommended. Combining microneedling with Minoxidil is common for improved results.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

7 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

View more "bulge cells" in community →

Learn

4 / 801 results

learn Stem Cell Factor

learn Fluocinolone

Can long-term use of Fluocinolone affect the health of hair follicles? There is no long-term human trial measuring what topical fluocinolone does to hair follicles; what is documented is the label's warning about skin atrophy with prolonged use, plus a 2007 mouse study suggesting hair-follicle bulge stem cells do not repair steroid-induced atrophy.

learn Beta Polypeptide

learn Thymosin Beta 4

View more "bulge cells" in learn →

Experts

— no results

Try a deeper search in experts →

Clinics

— no results

Try a deeper search in clinics →