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    Glossary Bulge Cells

    specialized stem cells in hair follicles aiding growth and repair

    Bulge cells are specialized stem cells located in the hair follicle's bulge area, which is a region near the base of the hair follicle. These cells play a crucial role in hair growth and regeneration, as they have the ability to differentiate into various cell types needed for the hair follicle's structure and function. For professionals, it's important to note that bulge cells are also involved in wound healing and can contribute to the regeneration of the epidermis.

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    1. Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles Differentiation · 1994 · 130 citations
    2. Canine Follicle Stem Cell Candidates Reside in the Bulge and Share Characteristic Features with Human Bulge Cells 2010 · 36 citations
    3. Differential expression of stem cell markers in human follicular bulge and interfollicular epidermal compartments Histochemistry and Cell Biology · 2010 · 28 citations
    4. Bulge cells of human hair follicles: segregation, cultivation and properties Colloids and Surfaces B: Biointerfaces · 2006 · 27 citations
    5. The Hair Follicle Bulge: A Niche for Adult Stem Cells Microscopy and Microanalysis · 2011 · 19 citations
    6. BULGE CELLS OF RAT HAIR FOLLICLES: ISOLATION, CULTIVATION, MORPHOLOGICAL AND BIOLOGICAL FEATURES 2010 · 17 citations
    7. Advances in the Study of Stem-Cell-Enriched Hair Follicle Bulge Cells: A Review Featuring Characterization and Isolation of Human Bulge Cells Dermatology · 2007 · 16 citations
    8. Genetically Induced Cell Death in Bulge Stem Cells Reveals Their Redundancy for Hair and Epidermal Regeneration Stem Cells · 2014 · 13 citations
    9. Epidermal structure created by canine hair follicle keratinocytes enriched with bulge cells in a three‐dimensional skin equivalent model <i>in vitro</i>: implications for regenerative therapy of canine epidermis Veterinary dermatology · 2013 · 11 citations
    10. The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z‐protein in cells of the bulge region 1999 · 5 citations
    11. Identification of Bulge Stem Cells in Mouse and Human Hair Follicles Microscopy research · 2018 · 4 citations
    12. Isolation, Cultivation, and Morphological Characteristics of Hair Follicle Adult Stem Cells in the Bulge Region in Mouse and Human Microscopy research · 2020 · 1 citations
    13. Role of bulge cells in wound healing: possible implications for hidradenitis suppurativa Experimental dermatology · 2006
    14. Hairy Math: Addition of Wnt-3a to Multiply Bulge Cells Journal of Investigative Dermatology · 2015
    15. Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation American Journal Of Pathology · 2011 · 54 citations
    16. Anagen hair follicle repair: Timely regenerative attempts from plastic extra‐bulge epithelial cells Experimental Dermatology · 2019 · 18 citations
    17. GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells npj regenerative medicine · 2020 · 7 citations
    18. The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z-protein in cells of the bulge region 1999 · 2 citations
    19. 1393 Lower proximal cup cells but not bulge stem cells regenerate hair follicles after chemotherapy injury Journal of Investigative Dermatology · 2018 · 1 citations
    20. Bulge Progenitor Cells: A Promising Frontier in Hair Follicle Regeneration and Clinical Translation Stem Cell Reviews and Reports · 2026
    21. Faculty Opinions recommendation of GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2021
    22. In vitro identification of a stem cell population from canine hair follicle bulge region 2017 · 5 citations
    23. Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling Pathway International Journal of Medical Sciences · 2013 · 57 citations
    24. Canine hair‐follicle keratinocytes enriched with bulge cells have the highly proliferative characteristic of stem cells Veterinary Dermatology · 2009 · 37 citations
    25. Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites Amino Acids · 2013 · 17 citations
    26. TR3 is preferentially expressed by bulge epithelial stem cells in human hair follicles Laboratory Investigation · 2016 · 7 citations
    27. Preliminary study on reconstruction of hair follicle by cell mass of dermal papilla cells and bulge stem cells Shiyong kouqiang yixue zazhi · 2011
    28. Dicer- and Bulge Stem Cell-Dependent MicroRNAs During Induced Anagen Hair Follicle Development Frontiers in cell and developmental biology · 2020 · 10 citations
    29. 732 Treatment with cyclohexyl salicylate, an olfactory receptor 2A4/7 agonist, promotes human hair follicle growth and bulge stem cell progeny expansion Journal of Investigative Dermatology · 2022
    30. Basal cell carcinoma possibly originates from the outer root sheath and/or the bulge region of the vellus hair follicle Archives of Dermatological Research · 1999 · 107 citations