550 citations
,
December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”
This study found that bulge cells marked by CD200+ in human hairfollicles show high colony-forming efficiency, suggesting successful enrichment of keratinocyte stem cells.
419 citations
,
March 2005 in “Proceedings of the National Academy of Sciences”
This study demonstrated that ND-GFP stem cells from the hair-folliclebulge area can differentiate into various cell types, including neurons, suggesting their potential as a source for therapeutic applications.
39 citations
,
November 2009 in “Clinical and Experimental Dermatology”
This study reports that in primary cicatricial alopecias, increased expression of certain immune markers in the hair-folliclebulge suggests a collapse of immune privilege, which may contribute to follicle destruction.
Hairfollicle regeneration through stem cell rearrangement is discussed, focusing on bioengineered cellular structures rather than traditional hair transplants. Treatments mentioned include Minoxidil, finasteride, and RU58841.
PP405 may damage hairfollicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.
Intermittent fasting may suppress hairfollicle regeneration, but opinions vary on its impact on hair loss. Some users report no negative effects or even hair improvement while using treatments like finasteride and minoxidil.
David Barreto shared that a London-based research group is conducting a 12-month trial for a new nutraceutical treatment for pattern hair loss, designed with Dr. Carlos Puig. The trial aims to provide robust data, with results expected in 1-2 years, potentially representing a significant advancement since finasteride’s introduction in 1997.
A new stem cell method for culturing hairfollicles is being developed as an alternative to Minoxidil, finasteride, and RU58841. There are concerns about its cost and accessibility despite plans for commercialization.
Can long-term use of Fluocinolone affect the health of hairfollicles?There is no long-term human trial measuring what topical fluocinolone does to hair follicles; what is documented is the label's warning about skin atrophy with prolonged use, plus a 2007 mouse study suggesting hair-follicle bulge stem cells do not repair steroid-induced atrophy.
Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.