Hair Follicle Bulge-Derived Stem Cells Promote Tissue Regeneration During Skin Expansion

October 2020 in “ Biomedicine & Pharmacotherapy ”

Xiaoxi Cheng, Zhou Yu, Yajuan Song, Yu Zhang, Jing Du, Yingjun Su, Xianjie Ma

hair follicle bulge-derived stem cells HFBSCs epidermal cells outer root sheath cells vascular endothelial cells epidermal thickness dermal thickness cell proliferation collagen content blood flow growth factors EGF epidermal growth factor VEGF vascular endothelial growth factor bFGF basic fibroblast growth factor TGF-β transforming growth factor beta

TLDR Hair follicle stem cells help skin heal and grow better.

The study investigated the effects of hair follicle bulge-derived stem cells (HFBSCs) on skin regeneration during expansion in a rat model. Transplantation of HFBSCs resulted in increased skin area, tissue weight, epidermal and dermal thickness, and collagen content, along with improved microcirculatory blood flow and reduced retraction ratios compared to controls. The transplanted HFBSCs differentiated into various cell types, including vascular endothelial and epidermal cells, and enhanced the expression of growth factors such as EGF, VEGF, bFGF, and TGF-β. These findings suggested that HFBSCs could significantly promote tissue regeneration in expanded skin, offering potential for improved reconstructive surgery outcomes.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

12 / 12 results

A Randomized, Double-Blind, Vehicle-Controlled Clinical Study of Hair Regeneration Using Adipose-Derived Stem Cell Constituent Extract in Androgenetic Alopecia

research A Randomized, Double-Blind, Vehicle-Controlled Clinical Study of Hair Regeneration Using Adipose-Derived Stem Cell Constituent Extract in Androgenetic Alopecia

25 citations, May 2020 in “Stem Cells Translational Medicine”

ADSC-CE treatment safely increases hair density and thickness in androgenetic alopecia patients.

Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

research Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

65 citations, April 2020 in “International Journal of Molecular Sciences”

PRP injections may be a safe, effective alternative for hair loss treatment compared to minoxidil and finasteride.

research Multimodal Imaging of Hair Follicle Bulge-Derived Stem Cells in a Mouse Model of Traumatic Brain Injury

4 citations, February 2020 in “Cell & tissue research/Cell and tissue research”

Hair follicle stem cells might help treat traumatic brain injury.

research Autologous Activated Platelet-Rich Plasma (AA-PRP) and Non-Activated (A-PRP) in Hair Growth: A Retrospective, Blinded, Randomized Evaluation in Androgenetic Alopecia

44 citations, February 2020 in “Expert Opinion on Biological Therapy”

PRP, especially AA-PRP, can help improve hair growth in androgenetic alopecia.

research Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and Female Androgenetic Alopecia

41 citations, January 2020 in “BioMed Research International”

Micrografts improve hair density and thickness without side effects.

research Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia

88 citations, July 2019 in “International Journal of Molecular Sciences”

Using human fat tissue derived stem cells in micrografts can safely and effectively increase hair density in people with hair loss.

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations, May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

research Are Hair Follicle Stem Cells Promising Candidates for Wound Healing?

18 citations, December 2018 in “Expert Opinion on Biological Therapy”

Hair follicle stem cells are promising for wound healing but require more research for safe clinical use.

Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

research Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

136 citations, February 2017 in “International Journal of Molecular Sciences”

PRP treatment improves hair growth, and the device used can affect results, with some being more effective.

research Stem Cell Therapy as a Novel Therapeutic Intervention for Resistant Cases of Alopecia Areata and Androgenetic Alopecia

39 citations, August 2016 in “Journal of Dermatological Treatment”

Stem cell therapy may help treat tough hair loss cases.

research The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial

214 citations, September 2015 in “Stem Cells Translational Medicine”

Platelet-rich plasma injections significantly improved hair regrowth and thickness in patients with hair loss.

research The Effect of Autologous Activated Platelet Rich Plasma Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation

183 citations, January 2014 in “BioMed Research International”

AA-PRP injections effectively increase hair count and thickness for male pattern hair loss.

Related Community Posts Join

6 / 1000+ results

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 10 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

in Technology 107 upvotes 11 months ago

CRISPR shows promise for treating hair loss by targeting specific genes. Current treatments include Minoxidil and finasteride, but CRISPR could offer a more precise solution, though it is still expensive and in early stages.

community You will lose hair if your prostaglandins aren't in balance

in Research/Science 54 upvotes 5 months ago

Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

community OFFICIAL Multi-Center Verteporfin Trial Recruitment

in Research/Science 251 upvotes 3 months ago

Recruitment for a verteporfin trial and a separate hair cloning trial using verteporfin and other methods is underway, with locations in Jordan, NYC, Beverly Hills, and Memphis. Dr. Bloxham is conducting the hair cloning trial, and interested participants are encouraged to contact him directly.

Related Research

1 / 1 results

research Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles

94 citations, February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

EGF makes hair follicles grow longer but stops hair production.