Hair Follicle Bulge-Derived Stem Cells Promote Tissue Regeneration During Skin Expansion

October 2020 in “ Biomedicine & Pharmacotherapy ”

Xiaoxi Cheng, Zhou Yu, Yajuan Song, Yu Zhang, Jing Du, Yingjun Su, Xianjie Ma

hair follicle bulge-derived stem cells HFBSCs epidermal cells outer root sheath cells vascular endothelial cells epidermal thickness dermal thickness cell proliferation collagen content blood flow growth factors EGF epidermal growth factor VEGF vascular endothelial growth factor bFGF basic fibroblast growth factor TGF-β transforming growth factor beta

TLDR Hair follicle stem cells help skin heal and grow better.

The study investigated the effects of hair follicle bulge-derived stem cells (HFBSCs) on skin regeneration during expansion in a rat model. Transplantation of HFBSCs resulted in increased skin area, tissue weight, epidermal and dermal thickness, and collagen content, along with improved microcirculatory blood flow and reduced retraction ratios compared to controls. The transplanted HFBSCs differentiated into various cell types, including vascular endothelial and epidermal cells, and enhanced the expression of growth factors such as EGF, VEGF, bFGF, and TGF-β. These findings suggested that HFBSCs could significantly promote tissue regeneration in expanded skin, offering potential for improved reconstructive surgery outcomes.

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