Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia

July 2019 in “ International Journal of Molecular Sciences ”

Pietro Gentile

autologous cellular method micrografts human adipose tissue derived follicle stem cells HD-AFSCs androgenic alopecia hair density CD34+ cells progenitor cells outer root sheath hair follicles stem cell therapy hair loss hair growth stem cells fat-derived stem cells

TLDR Using human fat tissue derived stem cells in micrografts can safely and effectively increase hair density in people with hair loss.

In 2019, a study was conducted on 35 patients (23 males and 12 females) aged 21-70 years, suffering from Androgenic Alopecia. The study used an autologous cellular method involving micrografts of human adipose tissue derived follicle stem cells (HD-AFSCs). The patients were treated with three injections at 45-day intervals. The results showed a significant improvement in hair density, with a mean increase of 33% ± 7.5% and 27% ± 3.5% at 23 and 44 weeks after the last injection, respectively. The study also found that the number of CD34+ cells, progenitor cells located in the outer root sheath of hair follicles, increased roughly 3-fold in the treated area compared to the baseline. The study concluded that HD-AFSCs contained in micro-grafts may represent a safe and effective alternative therapy option against hair loss, but further research is needed to fully understand the mechanisms and optimize the procedures.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

18 / 18 results

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations, May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

research Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

69 citations, April 2019 in “Biomedicines”

PRP and HF-MSCs treatment improves hair growth, thickness, and density in androgenetic alopecia.

research Conventional and Novel Stem Cell-Based Therapies for Androgenic Alopecia

22 citations, August 2017 in “Stem cells and cloning”

Stem cell technologies and regenerative medicine, including platelet-rich plasma, show promise for hair restoration in treating hair loss, but more research is needed.

research Hair Follicle Growth by Stromal Vascular Fraction-Enhanced Adipose Transplantation in Baldness

30 citations, July 2017 in “Stem cells and cloning”

SVF-enhanced adipose transplantation shows potential as a hair loss treatment.

Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss

research Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss

86 citations, June 2017 in “Stem cell investigation”

Stem cells from hair follicles can safely treat hair loss.

Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

research Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

136 citations, February 2017 in “International Journal of Molecular Sciences”

PRP treatment improves hair growth, and the device used can affect results, with some being more effective.

research Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid

42 citations, January 2017 in “Stem cells international”

Adding hyaluronic acid helps create larger artificial hair follicles in the lab.

research The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial

214 citations, September 2015 in “Stem Cells Translational Medicine”

Platelet-rich plasma injections significantly improved hair regrowth and thickness in patients with hair loss.

research Epidermal Stem Cells and Skin Tissue Engineering in Hair Follicle Regeneration

83 citations, January 2015 in “World Journal of Stem Cells”

Hair follicle regeneration needs special conditions and young cells.

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

499 citations, September 2011 in “Cell”

Fat-related cells are important for initiating hair growth.

Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

research Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

235 citations, January 2011 in “Journal of Clinical Investigation”

Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.

research Androgens and Hair Loss: An In-Depth Analysis of Androgenetic Alopecia

52 citations, June 2009 in “Current Opinion in Endocrinology, Diabetes and Obesity”

The document concludes that hair transplantation and gene therapy may be important for future hair loss treatment.

research The Hair Cycle

375 citations, February 2006 in “Journal of Cell Science”

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

550 citations, December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.

research Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling

277 citations, June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations, August 2000 in “Cell”

Hair follicle stem cells can form both hair follicles and skin.

research Treatment of Hair Loss

370 citations, September 1999 in “The New England Journal of Medicine”

Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.

research The Biology of Hair Follicles

1113 citations, August 1999 in “The New England Journal of Medicine”

Hair follicle biology advancements may lead to better hair growth disorder treatments.

Related Research

8 / 8 results

research Scalp Vascularization as a Marker of Topical Minoxidil Treatment Efficacy in Patients with Androgenetic Alopecia

March 2021 in “Postepy Dermatologii I Alergologii”

Minoxidil works equally well for hair growth regardless of scalp blood flow.

research Hair Loss and Hirsutism Management

January 2019

Low-level light therapy, possibly combined with other treatments, may become a leading hair loss treatment, while hirsutism often worsens with age and lacks preventive options.

research Hair Disorders

August 2018 in “Oxford University Press eBooks”

The document's conclusion cannot be provided because the document cannot be parsed.

research Hair Loss (Alopecia or Baldness)

June 2018

Baldness is often hereditary and linked to male hormones, becoming noticeable when half the hair is lost.

research Standardization of Trichotillometer

March 2009

Trichotillometry can measure hair plucking force, aiding alopecia treatment evaluation.

research Characteristic Features of Japanese Women's Hair With Aging and Hair Loss

76 citations, December 2006 in “Journal of Dermatological Science”

Japanese women typically start experiencing hair loss after 40, with reduced hair density and thickness being the main factors.

research Female-Patterned Alopecia in Teenage Brothers with Unusual Histologic Features

6 citations, August 2006 in “Journal of Cutaneous Pathology”

Two teenage brothers had a rare, treatment-resistant form of female-pattern hair loss with unusual scalp changes.

research Evaluation of Hair Loss

21 citations, May 1996 in “Current problems in dermatology”

Detailed patient history and physical exams are crucial for diagnosing hair loss.