Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid

    January 2017 in “ Stem cells international ”
    Ekaterina P. Kalabusheva, В. В. Терских, E. A. Vorotelyak
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    TLDR Adding hyaluronic acid helps create larger artificial hair follicles in the lab.
    In a study from 2017, researchers developed an artificial hair follicle germ in vitro by combining human dermal papilla (DP) cells and skin epidermal keratinocytes (KCs) using a hanging drop culture technique. This method leveraged the hair-inducing properties of DP cells and the self-organizing ability of KCs. The team evaluated two protocols for assembling the germ-like structures and found that these structures initiated epithelial-mesenchymal interaction, including WNT pathway activation and expression of follicular markers. They investigated the role of DP cell niche components, such as soluble factors and extracellular matrix (ECM) molecules, in organoid assembly and growth. Soluble factors had minimal impact on hair follicle germ generation and cell proliferation within the organoids, although BMP6 and VD3 effectively maintained DP cell identity in monolayer culture. ECM compounds generally inhibited cell aggregate formation, but hyaluronic acid (HA) was found to promote the formation of larger organoids. The study concluded that their model could be useful for studying cell-cell and cell-niche interactions during hair follicle reconstruction in vitro.
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