Advances in a Rapidly Emerging Field of Hair Follicle Stem Cell Research

March 2014 in “ PubMed ”

Zrinka Bukvić Mokoš, Elvira Lazić Mosler

hair follicle stem cells epidermal stem cells bioengineered hair follicular unit transplantation wound repair gene therapy epidermolysis bullosa keratin 15 CD34 CD200 bulge cells alopecia tissue engineering HFSC FUT

TLDR Hair follicle stem cell research has advanced in understanding and using these cells for hair growth and skin repair.

The document discussed the advancements in hair follicle stem cell (HFSC) research, highlighting both basic and clinical progress. In basic science, significant developments included the ability to assay epidermal stem cells in vivo, identify independent interfollicular epidermal stem cells, and analyze individual stem cell divisions. Notably, bioengineered hair follicular unit transplantation (FUT) in mice was a breakthrough. Clinically, stem cells were recognized for their role in wound repair and gene therapy for inherited skin diseases like epidermolysis bullosa. The study of HFSCs advanced with the identification of molecular markers such as keratin 15 (K15) and CD34 in mice, and CD200 in humans, facilitating the isolation and characterization of bulge cells. The paper provided an overview of epidermal stem cells in hair follicles, their characteristics, control of their fate, their role in alopecia, and their application in tissue engineering.

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Research cited in this study

2 / 2 results

research Drug Discovery for Alopecia: Gone Today, Hair Tomorrow

70 citations , February 2015 in “Expert Opinion on Drug Discovery”

Topical drugs and near-infrared light therapy show potential for treating alopecia.

research Follicular Unit Transplantation

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Follicular Unit Transplantation (FUT) can give great results and patient satisfaction when done carefully and by a skilled surgeon.

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