The Up-Regulation of 14-3-3 Proteins in Smad4 Deficient Epidermis and Hair Follicles at Catagen

    April 2008 in “ PROTEOMICS ”
    Cunzhong Yuan, Liyan Jiao, Leilei Yang, Wantao Ying, Zhishang Hu, Jinfeng Liu, Fang Cui, Lei Li, Linyi Qian, Yan Teng, Haiying Hang, Xiaohong Qian, Xiao Yang
    TLDR Increased 14-3-3 proteins may block hair cycle regression, causing hair loss.
    The study investigated the molecular events in hair follicles (HFs) of Smad4 knockout mice, which exhibited progressive alopecia due to a failure in programmed regression during the hair cycle. Using 2-D difference gel electrophoresis proteomic analysis, researchers identified 86 differentially expressed protein spots, corresponding to 72 proteins, with 29 proteins showing changes during the anagen-catagen transition in Smad4 mutants. The study highlighted that 14-3-3 proteins, specifically 14-3-3σ, 14-3-3ζ, and 14-3-3β, were significantly down-regulated in wild-type keratinocytes but not in Smad4 mutants during the catagen phase. This suggested that the up-regulation of 14-3-3 proteins might contribute to the blockade of catagen initiation in Smad4 deficient HFs, providing insights into the molecular mechanisms underlying hair follicle regression and alopecia.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 1000+ results

      community Creatine's effect on Hair Loss and DHT

      in Research/Science  100 upvotes 1 year ago
      A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

      community Verteporfin and Microneedling

      in Treatments 1 year ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

      in Research/Science  125 upvotes 2 years ago
      The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

    Related Research

    7 / 7 results