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research Caffeic acid N-[3,5-bis(trifluoromethyl)phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics

December 2022 in “Scientific Reports”

This study found that caffeic acid amide derivative, compound 4, effectively inhibited steroid 5α-reductase type 1 in vitro, suggesting potential for development as a treatment for androgenic alopecia.

research Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

24 citations , September 2005 in “Journal of Cellular Biochemistry”

This study found that all-trans and 9-cis retinoic acids increase steroid sulfatase activity in HL60 cells through mechanisms involving RARα/RXR heterodimers and multiple signaling pathways.

research Hair Growth Defects in Insig-Deficient Mice Caused by Cholesterol Precursor Accumulation and Reversed by Simvastatin

46 citations , January 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that Insig deficiency in the skin of mice causes cholesterol precursors to accumulate, leading to defective hair development and skin abnormalities, which were alleviated by simvastatin treatment.

research Expression of truncated latent TGF-β-binding protein modulates TGF-β signaling

40 citations , May 2005 in “Journal of Cell Science”

In this study, transgenic mice expressing a truncated form of latent transforming growth factor-β-binding protein exhibited altered hair cycles due to increased active transforming growth factor-β, impacting keratinocyte proliferation and hair cycle phases.

research Preparation and Characterization of Solution-Processed Nanocrystalline p-Type CuAlO2 Thin-Film Transistors

14 citations , August 2018 in “Nanoscale Research Letters”

This study reported that optimized nanocrystalline CuAlO2 thin-film transistors exhibited a threshold voltage of −1.3 V and may contribute to advancements in low-cost complementary metal oxide semiconductor logic circuits.

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community Big increase in miniaturization after being on finasteride for 7 years?

in Finasteride/Dutasteride 29 upvotes 1 year ago

The user experienced increased hair miniaturization and shedding despite using finasteride, topical minoxidil, microneedling, and other treatments. They are considering more aggressive treatments or a hair system if no improvement occurs by the end of 2025.

community I've been afraid to start Finasteride treatment for 5 years, on it for 2 weeks, regret that hadn't started it earlier and here's my story

31 upvotes 5 years ago

A 28-year-old male, losing hair since his teens, started taking 0.31 mg finasteride daily for two weeks with no side effects and regrets not starting earlier. He tried various treatments like minoxidil, scalp massages, and vitamins but found finasteride most effective.

community 2 months Dutasteride - hyperresponder?

in Progress Pictures 148 upvotes 4 months ago

OP experienced significant hair growth after switching from topical treatments to oral Dutasteride, alongside using CJC/Ipamorelin and Cialis. They stopped using topical Minoxidil and Finasteride, attributing the hair growth to the new regimen.

community [18M] 3 months progress. Went from looking like a 35yo divorced dad to having a better hairline than at 14.

in Progress Pictures 151 upvotes 7 months ago

An 18-year-old shared his 3-month hair regrowth progress using Kirkland 5% topical minoxidil and a dermaroller, achieving a better hairline without finasteride. He plans to switch from liquid to foam minoxidil for easier styling and is cautious about starting finasteride due to potential hormonal effects.

community Please help! Continuously thinning while on Fin 1 mg

in Finasteride/Dutasteride 7 upvotes 7 months ago

The user is experiencing continued hair thinning despite taking Finasteride 1 mg daily for over a year and is hesitant to try Minoxidil due to potential side effects and inconsistency. Suggestions include trying topical Minoxidil once a day, considering oral Minoxidil, and possibly getting a skin biopsy to determine the type of hair loss.

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Learn

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learn Hair Transplant

What happens after a hair transplant? Expect mild swelling and redness, with new hair growth starting in 3 to 6 months.
How should I sleep after a hair transplant? Sleep with your head elevated and on your back for the first 3-15 nights.

learn Dutasteride

Dutasteride side effects: what the label and studies actually report The Avodart label reports impotence in 4.7% and decreased libido in 3.0% of men in the first six months (1.7% and 1.4% on placebo), with new reports falling after month six; those figures come from BPH trials in older men, and the hair-loss trials in younger men run only six months. The label and studies also flag a PSA drop of about half, a small rise in high-grade prostate cancer in one trial, an observational link to depression, and sexual effects that the label says may persist after stopping.

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SMP
No. 14 Hair ClinicSouthampton, England · GB

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