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Glossary Arachidonic Acid

polyunsaturated omega-6 fatty acid involved in inflammation and signaling

Arachidonic Acid (AA) is a polyunsaturated omega-6 fatty acid that is a key component of cell membranes. It plays a crucial role in the body's inflammatory response and is a precursor to various signaling molecules called eicosanoids, which include prostaglandins, thromboxanes, and leukotrienes. These molecules are involved in processes such as inflammation, immunity, and the regulation of blood pressure.

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5 / 650 results

research A Keratinocyte-specific Epoxygenase, CYP2B12, Metabolizes Arachidonic Acid with Unusual Selectivity, Producing a Single Major Epoxyeicosatrienoic Acid

58 citations , April 1998 in “Journal of biological chemistry/The Journal of biological chemistry”

This study identified that the enzyme CYP2B12 is skin-specific and likely plays a role in the metabolism of arachidonic acid, a key component in lipid signaling within sebaceous glands.

research Role of Arachidonic Acid in Promoting Hair Growth

29 citations , January 2016 in “Annals of dermatology/Annals of Dermatology”

This study found that arachidonic acid may promote hair growth by enhancing dermal papilla cell function and stimulating the anagen phase in C57BL/6 mice.

research Effect of VEGF and minoxidil on the production of arachidonic acid metabolites by cultured hair, dermal papilla cells

1 citations , January 1996 in “European Journal of Dermatology”

This study found that VEGF activated and minoxidil differentially modulated arachidonic acid metabolite production in hair dermal papilla cells, enhancing PGE2 and LTB4 but reducing PG6KF1α.

research Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin

January 2025 in “Cellular & Molecular Biology Letters”

This review discusses how dysregulated levels of eicosanoids, which are metabolites of phospholipids, may contribute to skin diseases like psoriasis and atopic dermatitis, suggesting the importance of targeted eicosanoid control in diagnosis and treatment.

research Loss of adipocyte phospholipase gene PLAAT3 causes lipodystrophy and insulin resistance due to inactivated arachidonic acid-mediated PPARγ signaling

April 2021

This study found that individuals with homozygous loss-of-function mutations in PLAAT3 experience a novel type of partial lipodystrophy linked to defects in white adipose tissue differentiation and function.

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community Painkillers May Block Minoxidil

12 upvotes 1 year ago

Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

3 upvotes 1 year ago

DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

community Topical melatonin shows some promise.

4 upvotes 10 years ago

Topical melatonin shows promise for increasing hair density with minimal side effects. The user is transitioning from oral finasteride to a compounded minoxidil and finasteride solution and considering melatonin and bimatoprost as additional treatments.

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